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• NCIT_C1319 IAO_0000115 "The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.
• NCIT_C1319 NCIT_A32 NCIT_C1909 @default.
• NCIT_C1319 NCIT_A6 NCIT_C62042 @default.
• NCIT_C1319 NCIT_A7 NCIT_C38910 @default.
• NCIT_C1319 NCIT_NHC0 "C1319" @default.
• NCIT_C1319 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
• NCIT_C1319 NCIT_P106 "Pharmacologic Substance" @default.
• NCIT_C1319 NCIT_P107 "Leuprolide Acetate" @default.
• NCIT_C1319 NCIT_P108 "Leuprolide Acetate" @default.
• NCIT_C1319 NCIT_P207 "C0700596" @default.
• NCIT_C1319 NCIT_P210 "74381-53-6" @default.
• NCIT_C1319 NCIT_P302 "Endometriosis; In-vitro fertilization; Precocious puberty; Premenstrual syndrome; Prostate cancer; Uterine fibroid tumors" @default.
• NCIT_C1319 NCIT_P319 "37JNS02E7V" @default.
• NCIT_C1319 NCIT_P322 "CTRP" @default.
• NCIT_C1319 NCIT_P322 "FDA" @default.
• NCIT_C1319 NCIT_P322 "GDC" @default.
• NCIT_C1319 NCIT_P325 "A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog." @default.
• NCIT_C1319 NCIT_P329 "40058" @default.
• NCIT_C1319 NCIT_P330 "40058" @default.
• NCIT_C1319 NCIT_P350 "C59H84N16O12.C2H4O2" @default.
• NCIT_C1319 NCIT_P366 "Leuprolide" @default.
• NCIT_C1319 NCIT_P368 "CHEBI:63597" @default.
• NCIT_C1319 NCIT_P375 "Leuprolide Acetate" @default.
• NCIT_C1319 NCIT_P399 "40058" @default.
• NCIT_C1319 NCIT_R124 NCIT_C17828 @default.
• NCIT_C1319 NCIT_R124 NCIT_C19143 @default.
• NCIT_C1319 NCIT_R124 NCIT_C21124 @default.
• NCIT_C1319 NCIT_R124 NCIT_C45549 @default.
• NCIT_C1319 NCIT_R125 NCIT_C17710 @default.
• NCIT_C1319 NCIT_R125 NCIT_C17828 @default.
• NCIT_C1319 NCIT_R125 NCIT_C18109 @default.
• NCIT_C1319 NCIT_R125 NCIT_C19405 @default.
• NCIT_C1319 NCIT_R125 NCIT_C19536 @default.
• NCIT_C1319 NCIT_R125 NCIT_C19958 @default.
• NCIT_C1319 NCIT_R125 NCIT_C20136 @default.
• NCIT_C1319 NCIT_R125 NCIT_C21198 @default.
• NCIT_C1319 NCIT_R125 NCIT_C28498 @default.
• NCIT_C1319 NCIT_R125 NCIT_C41476 @default.
• NCIT_C1319 NCIT_R125 NCIT_C41524 @default.
• NCIT_C1319 NCIT_R146 NCIT_C17021 @default.
• NCIT_C1319 NCIT_R146 NCIT_C17728 @default.
• NCIT_C1319 NCIT_R146 NCIT_C18106 @default.
• NCIT_C1319 NCIT_R146 NCIT_C18239 @default.
• NCIT_C1319 NCIT_R146 NCIT_C20027 @default.
• NCIT_C1319 NCIT_R146 NCIT_C26548 @default.
• NCIT_C1319 NCIT_R146 NCIT_C38910 @default.
• NCIT_C1319 normalizedInformationContent "77.950262499983424" @default.
• NCIT_C1319 referenceCount "28" @default.
• NCIT_C1319 hasExactSynonym "6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig) Monoacetate" @default.
• NCIT_C1319 hasExactSynonym "6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) Monoacetate" @default.
• NCIT_C1319 hasExactSynonym "A-43818" @default.
• NCIT_C1319 hasExactSynonym "Abbott 43818" @default.
• NCIT_C1319 hasExactSynonym "Abbott-43818" @default.
• NCIT_C1319 hasExactSynonym "Carcinil" @default.
• NCIT_C1319 hasExactSynonym "Depo-Eligard" @default.
• NCIT_C1319 hasExactSynonym "Eligard" @default.
• NCIT_C1319 hasExactSynonym "Enanton" @default.
• NCIT_C1319 hasExactSynonym "Enantone" @default.
• NCIT_C1319 hasExactSynonym "Enantone-Gyn" @default.
• NCIT_C1319 hasExactSynonym "Ginecrin" @default.
• NCIT_C1319 hasExactSynonym "LEUP" @default.
• NCIT_C1319 hasExactSynonym "LEUPROLIDE ACETATE" @default.
• NCIT_C1319 hasExactSynonym "Leuplin" @default.
• NCIT_C1319 hasExactSynonym "Leuprolide Acetate" @default.
• NCIT_C1319 hasExactSynonym "Leuprorelin Acetate" @default.
• NCIT_C1319 hasExactSynonym "Lucrin Depot" @default.
• NCIT_C1319 hasExactSynonym "Lucrin" @default.
• NCIT_C1319 hasExactSynonym "Luprodex Depot" @default.
• NCIT_C1319 hasExactSynonym "Lupron Depot" @default.
• NCIT_C1319 hasExactSynonym "Lupron Depot-3 Month" @default.
• NCIT_C1319 hasExactSynonym "Lupron Depot-4 Month" @default.
• NCIT_C1319 hasExactSynonym "Lupron Depot-Ped" @default.
• NCIT_C1319 hasExactSynonym "Lupron" @default.
• NCIT_C1319 hasExactSynonym "Lutrate" @default.
• NCIT_C1319 hasExactSynonym "Procren" @default.
• NCIT_C1319 hasExactSynonym "Procrin" @default.
• NCIT_C1319 hasExactSynonym "Prostap" @default.
• NCIT_C1319 hasExactSynonym "TAP-144" @default.
• NCIT_C1319 hasExactSynonym "Trenantone" @default.
• NCIT_C1319 hasExactSynonym "Uno-Enantone" @default.
• NCIT_C1319 hasExactSynonym "Viadur" @default.
• NCIT_C1319 hasExactSynonym "leuprolide acetate" @default.
• NCIT_C1319 inSubset NCIT_C116977 @default.
• NCIT_C1319 inSubset NCIT_C116978 @default.
• NCIT_C1319 inSubset NCIT_C128784 @default.
• NCIT_C1319 inSubset NCIT_C157711 @default.
• NCIT_C1319 inSubset NCIT_C157712 @default.
• NCIT_C1319 inSubset NCIT_C176424 @default.
• NCIT_C1319 inSubset NCIT_C177537 @default.
• NCIT_C1319 inSubset NCIT_C63923 @default.
• NCIT_C1319 type Class @default.
• NCIT_C1319 isDefinedBy ncit.owl @default.
• NCIT_C1319 label "Leuprolide Acetate" @default.
• NCIT_C1319 subClassOf B221c668e60375a13d40866ca5e7ec000 @default.
• NCIT_C1319 subClassOf B49cdbdf8d67f283d57cbcb282a83f7ba @default.
• NCIT_C1319 subClassOf B6461c568a6cc430ebd28780bdc353d9a @default.
• NCIT_C1319 subClassOf B6cd1c6f9ae7143454385b85d61627ca1 @default.
• NCIT_C1319 subClassOf B875c17d0bbb7fd65f2633ea1a8a51227 @default.
• NCIT_C1319 subClassOf Bafec2ff610b3a8547e402bc01220850b @default.
• NCIT_C1319 subClassOf Be5491aecf20c8635682b657953ab0528 @default.

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