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- NCIT_C131910 IAO_0000115 "An orally bioavailable agonist of the nuclear receptor liver X receptor beta (LXRbeta; NR1H2; LXR-b), with potential immunomodulating and antineoplastic activities. Upon oral administration, abequolixron selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells. LXRbeta, a member of the oxysterol receptor family, which is in the nuclear receptor family of transcription factors, plays a key role in cholesterol transport, glucose metabolism and the modulation of inflammatory responses; activation of LXRbeta suppresses tumor cell invasion, angiogenesis, tumor progression, and metastasis in a variety of tumor cell types. The expression of the ApoE protein becomes silenced in human cancers as they grow, become invasive, and metastasize; ApoE silencing is related to reduced survival in cancer patients. The LXR-ApoE pathway regulates the ability of cancers to evade the immune system and recruit blood vessels." @default.
- NCIT_C131910 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131910 NCIT_NHC0 "C131910" @default.
- NCIT_C131910 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131910 NCIT_P108 "Abequolixron" @default.
- NCIT_C131910 NCIT_P208 "CL520758" @default.
- NCIT_C131910 NCIT_P210 "610318-54-2" @default.
- NCIT_C131910 NCIT_P319 "Q26B92650V" @default.
- NCIT_C131910 NCIT_P322 "FDA" @default.
- NCIT_C131910 NCIT_P322 "GDC" @default.
- NCIT_C131910 NCIT_P329 "786379" @default.
- NCIT_C131910 NCIT_P330 "786379" @default.
- NCIT_C131910 NCIT_P375 "Liver X Receptor beta Agonist RGX-104" @default.
- NCIT_C131910 NCIT_P399 "786379" @default.
- NCIT_C131910 normalizedInformationContent "100" @default.
- NCIT_C131910 referenceCount "1" @default.
- NCIT_C131910 hasExactSynonym "ABEQUOLIXRON" @default.
- NCIT_C131910 hasExactSynonym "Abequolixron" @default.
- NCIT_C131910 hasExactSynonym "LXR-b Agonist RGX-104" @default.
- NCIT_C131910 hasExactSynonym "Liver X Receptor beta Agonist RGX-104" @default.
- NCIT_C131910 hasExactSynonym "RGX 104" @default.
- NCIT_C131910 hasExactSynonym "RGX-104" @default.
- NCIT_C131910 hasExactSynonym "RGX104" @default.
- NCIT_C131910 hasExactSynonym "SB-742881" @default.
- NCIT_C131910 inSubset NCIT_C128784 @default.
- NCIT_C131910 inSubset NCIT_C157711 @default.
- NCIT_C131910 inSubset NCIT_C157712 @default.
- NCIT_C131910 inSubset NCIT_C176424 @default.
- NCIT_C131910 inSubset NCIT_C177537 @default.
- NCIT_C131910 inSubset NCIT_C63923 @default.
- NCIT_C131910 type Class @default.
- NCIT_C131910 isDefinedBy ncit.owl @default.
- NCIT_C131910 label "Abequolixron" @default.
- NCIT_C131910 subClassOf NCIT_C129820 @default.
- NCIT_C131910 subClassOf NCIT_C131910 @default.
- NCIT_C131910 subClassOf NCIT_C1908 @default.
- NCIT_C131910 subClassOf NCIT_C1909 @default.
- NCIT_C131910 subClassOf NCIT_C274 @default.
- NCIT_C131910 subClassOf NCIT_C308 @default.