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- NCIT_C132017 IAO_0000115 "An antibody-drug conjugate (ADC), consisting of a human monoclonal antibody directed against AXL receptor tyrosine kinase (AXL; UFO) and conjugated, through a protease-cleavable linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of enapotamab vedotin binds to AXL, which is expressed on the surfaces of a variety of cancer cell types. Upon endocytosis and enzymatic cleavage, MMAE is released into the tumor cell cytosol, where it binds to tubulin and inhibits tubulin polymerization; this may result in G2/M phase arrest and apoptosis. AXL, a member of the TAM (TYRO3, AXL and MER) family of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis." @default.
- NCIT_C132017 NCIT_A7 NCIT_C17475 @default.
- NCIT_C132017 NCIT_NHC0 "C132017" @default.
- NCIT_C132017 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132017 NCIT_P107 "Enapotamab Vedotin" @default.
- NCIT_C132017 NCIT_P108 "Enapotamab Vedotin" @default.
- NCIT_C132017 NCIT_P208 "CL520570" @default.
- NCIT_C132017 NCIT_P210 "1912424-97-5" @default.
- NCIT_C132017 NCIT_P319 "43HH4XYH2N" @default.
- NCIT_C132017 NCIT_P322 "CTRP" @default.
- NCIT_C132017 NCIT_P322 "FDA" @default.
- NCIT_C132017 NCIT_P329 "786840" @default.
- NCIT_C132017 NCIT_P330 "786840" @default.
- NCIT_C132017 NCIT_P399 "786840" @default.
- NCIT_C132017 normalizedInformationContent "100" @default.
- NCIT_C132017 referenceCount "1" @default.
- NCIT_C132017 hasExactSynonym "Anti-AXL/MMAE ADC" @default.
- NCIT_C132017 hasExactSynonym "Anti-AXL/MMAE Antibody-Drug Conjugate" @default.
- NCIT_C132017 hasExactSynonym "ENAPOTAMAB VEDOTIN" @default.
- NCIT_C132017 hasExactSynonym "Enapotamab Vedotin" @default.
- NCIT_C132017 hasExactSynonym "HuMax-AXL-ADC" @default.
- NCIT_C132017 hasExactSynonym "Immunoglobulin G1, Anti-(Human Growth Factor Receptor axl)(Human Humax-axl Gamma1-chain), Disulfide with Human Humax-axl Kappa-chain, Dimer Tetrakis(thioether) with Vedotin" @default.
- NCIT_C132017 inSubset NCIT_C116977 @default.
- NCIT_C132017 inSubset NCIT_C116978 @default.
- NCIT_C132017 inSubset NCIT_C128784 @default.
- NCIT_C132017 inSubset NCIT_C176424 @default.
- NCIT_C132017 inSubset NCIT_C63923 @default.
- NCIT_C132017 type Class @default.
- NCIT_C132017 isDefinedBy ncit.owl @default.
- NCIT_C132017 label "Enapotamab Vedotin" @default.
- NCIT_C132017 subClassOf NCIT_C129821 @default.
- NCIT_C132017 subClassOf NCIT_C129823 @default.
- NCIT_C132017 subClassOf NCIT_C132017 @default.
- NCIT_C132017 subClassOf NCIT_C1512 @default.
- NCIT_C132017 subClassOf NCIT_C1908 @default.
- NCIT_C132017 subClassOf NCIT_C1909 @default.
- NCIT_C132017 subClassOf NCIT_C201141 @default.
- NCIT_C132017 subClassOf NCIT_C274 @default.
- NCIT_C132017 subClassOf NCIT_C307 @default.
- NCIT_C132017 subClassOf NCIT_C308 @default.