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- NCIT_C132023 IAO_0000115 "An orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations, including the resistance mutation T790M, and the L858R and del 19 mutations, with potential antineoplastic activity. Upon administration, the EGFR mutant-specific inhibitor CK-101 specifically and covalently binds to and inhibits selective EGFR mutations, with particularly high selectivity against the T790M mutation, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, CK-101 may have therapeutic benefits in tumors with T790M-mediated drug resistance. This agent shows minimal activity against wild-type EGFR (WT EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which also inhibit WT EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C132023 NCIT_A32 NCIT_C1909 @default.
- NCIT_C132023 NCIT_A7 NCIT_C128662 @default.
- NCIT_C132023 NCIT_A7 NCIT_C98503 @default.
- NCIT_C132023 NCIT_A7 NCIT_C98515 @default.
- NCIT_C132023 NCIT_NHC0 "C132023" @default.
- NCIT_C132023 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132023 NCIT_P107 "EGFR Mutant-specific Inhibitor CK-101" @default.
- NCIT_C132023 NCIT_P108 "EGFR Mutant-specific Inhibitor CK-101" @default.
- NCIT_C132023 NCIT_P208 "CL521020" @default.
- NCIT_C132023 NCIT_P210 "1660963-42-7" @default.
- NCIT_C132023 NCIT_P319 "708TLB8J3Y" @default.
- NCIT_C132023 NCIT_P322 "CTRP" @default.
- NCIT_C132023 NCIT_P322 "FDA" @default.
- NCIT_C132023 NCIT_P322 "GDC" @default.
- NCIT_C132023 NCIT_P329 "786517" @default.
- NCIT_C132023 NCIT_P330 "786517" @default.
- NCIT_C132023 NCIT_P375 "EGFR Mutant-specific Inhibitor CK-101" @default.
- NCIT_C132023 NCIT_P399 "786517" @default.
- NCIT_C132023 normalizedInformationContent "100" @default.
- NCIT_C132023 referenceCount "1" @default.
- NCIT_C132023 hasExactSynonym "CK 101" @default.
- NCIT_C132023 hasExactSynonym "CK-101" @default.
- NCIT_C132023 hasExactSynonym "CK101" @default.
- NCIT_C132023 hasExactSynonym "EGFR Mutant-specific Inhibitor CK-101" @default.
- NCIT_C132023 hasExactSynonym "OLAFERTINIB" @default.
- NCIT_C132023 hasExactSynonym "RX-518" @default.
- NCIT_C132023 inSubset NCIT_C116977 @default.
- NCIT_C132023 inSubset NCIT_C116978 @default.
- NCIT_C132023 inSubset NCIT_C128784 @default.
- NCIT_C132023 inSubset NCIT_C157711 @default.
- NCIT_C132023 inSubset NCIT_C157712 @default.
- NCIT_C132023 inSubset NCIT_C176424 @default.
- NCIT_C132023 inSubset NCIT_C177537 @default.
- NCIT_C132023 inSubset NCIT_C63923 @default.
- NCIT_C132023 type Class @default.
- NCIT_C132023 isDefinedBy ncit.owl @default.
- NCIT_C132023 label "EGFR Mutant-specific Inhibitor CK-101" @default.
- NCIT_C132023 subClassOf NCIT_C129824 @default.
- NCIT_C132023 subClassOf NCIT_C129825 @default.
- NCIT_C132023 subClassOf NCIT_C132023 @default.
- NCIT_C132023 subClassOf NCIT_C1404 @default.
- NCIT_C132023 subClassOf NCIT_C163758 @default.
- NCIT_C132023 subClassOf NCIT_C163952 @default.
- NCIT_C132023 subClassOf NCIT_C1908 @default.
- NCIT_C132023 subClassOf NCIT_C1909 @default.
- NCIT_C132023 subClassOf NCIT_C1967 @default.
- NCIT_C132023 subClassOf NCIT_C2167 @default.
- NCIT_C132023 subClassOf NCIT_C2189 @default.
- NCIT_C132023 subClassOf NCIT_C274 @default.
- NCIT_C132023 subClassOf NCIT_C471 @default.