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- NCIT_C132029 IAO_0000115 "A radiolabeled recombinant EGFR-specific affibody molecule composed of an epidermal growth factor receptor (EGFR)-targeting protein, the anti-EGFR affibody ZEGFR:1907 with an acetylated cysteine (Ac-Cys) at the N terminal of the affibody, and conjugated to the radioisotope gallium Ga 68, via the chelating agent NODAGA (1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid), with potential use for imaging EGFR-expressing tumor cells upon positron emission tomography (PET). Upon administration of gallium Ga 68-NODAGA-Ac-Cys-ZEGFR:1907, the ZEGFR:1907 affibody molecule moiety targets and binds to the extracellular domain (ECD) of EGFR expressed on various tumor cell types. Upon PET, EGFR-expressing tumor cells can be visualized. EGFR, frequently overexpressed in cancers, plays important roles in cell proliferation, survival, adhesion, migration, and differentiation. The affibody protein scaffold is based on the Z-domain, which is derived from one of the immunoglobulin (Ig) G-binding domains of staphylococcal protein A." @default.
- NCIT_C132029 NCIT_NHC0 "C132029" @default.
- NCIT_C132029 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C132029 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132029 NCIT_P108 "Gallium Ga 68-NODAGA-Ac-Cys-ZEGFR:1907" @default.
- NCIT_C132029 NCIT_P208 "CL520663" @default.
- NCIT_C132029 NCIT_P329 "786720" @default.
- NCIT_C132029 NCIT_P330 "786720" @default.
- NCIT_C132029 NCIT_P399 "786720" @default.
- NCIT_C132029 normalizedInformationContent "100" @default.
- NCIT_C132029 referenceCount "1" @default.
- NCIT_C132029 hasExactSynonym "68Ga-NODAGA-Ac-Cys-ZEGFR:1907" @default.
- NCIT_C132029 hasExactSynonym "Gallium Ga 68-NODAGA-Ac-Cys-Z(EGFR:1907)" @default.
- NCIT_C132029 hasExactSynonym "Gallium Ga 68-NODAGA-Ac-Cys-ZEGFR:1907" @default.
- NCIT_C132029 hasExactSynonym "[68Ga]-labeled Anti-EGFR Affibody Molecule Ac-Cys-ZEGFR:1907" @default.
- NCIT_C132029 inSubset NCIT_C176424 @default.
- NCIT_C132029 type Class @default.
- NCIT_C132029 isDefinedBy ncit.owl @default.
- NCIT_C132029 label "Gallium Ga 68-NODAGA-Ac-Cys-ZEGFR:1907" @default.
- NCIT_C132029 subClassOf NCIT_C132029 @default.
- NCIT_C132029 subClassOf NCIT_C1446 @default.
- NCIT_C132029 subClassOf NCIT_C1908 @default.
- NCIT_C132029 subClassOf NCIT_C1909 @default.
- NCIT_C132029 subClassOf NCIT_C1937 @default.
- NCIT_C132029 subClassOf NCIT_C2124 @default.
- NCIT_C132029 subClassOf NCIT_C45678 @default.
- NCIT_C132029 subClassOf NCIT_C802 @default.