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- NCIT_C1321 IAO_0000115 "A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell subset, followed by cytokine release, and subsequently inhibition of T cell functions. This agent may cause the opsonization and elimination of CD3-positive T cells from the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction." @default.
- NCIT_C1321 NCIT_NHC0 "C1321" @default.
- NCIT_C1321 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1321 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C1321 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1321 NCIT_P107 "Muromonab-CD3" @default.
- NCIT_C1321 NCIT_P108 "Muromonab-CD3" @default.
- NCIT_C1321 NCIT_P175 "618843" @default.
- NCIT_C1321 NCIT_P207 "C0085379" @default.
- NCIT_C1321 NCIT_P210 "140608-64-6" @default.
- NCIT_C1321 NCIT_P302 "Allograft rejection" @default.
- NCIT_C1321 NCIT_P319 "JGA39ICE2V" @default.
- NCIT_C1321 NCIT_P322 "CTRP" @default.
- NCIT_C1321 NCIT_P322 "FDA" @default.
- NCIT_C1321 NCIT_P325 "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells." @default.
- NCIT_C1321 NCIT_P329 "39580" @default.
- NCIT_C1321 NCIT_P330 "39580" @default.
- NCIT_C1321 NCIT_P366 "Monoclonal_Antibody_OKT3" @default.
- NCIT_C1321 NCIT_P399 "39580" @default.
- NCIT_C1321 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1321 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1321 NCIT_R124 NCIT_C18219 @default.
- NCIT_C1321 NCIT_R124 NCIT_C19986 @default.
- NCIT_C1321 NCIT_R124 NCIT_C40474 @default.
- NCIT_C1321 normalizedInformationContent "87.123597049860606" @default.
- NCIT_C1321 referenceCount "7" @default.
- NCIT_C1321 hasExactSynonym "Anti-CD3 Monoclonal Antibody OKT3" @default.
- NCIT_C1321 hasExactSynonym "MUROMONAB-CD3" @default.
- NCIT_C1321 hasExactSynonym "MoAb OKT3" @default.
- NCIT_C1321 hasExactSynonym "Monoclonal Antibody OKT3" @default.
- NCIT_C1321 hasExactSynonym "Muromonab-CD3" @default.
- NCIT_C1321 hasExactSynonym "Orthoclone OKT3" @default.
- NCIT_C1321 hasExactSynonym "muromonab-CD3 monoclonal antibody" @default.
- NCIT_C1321 inSubset NCIT_C116977 @default.
- NCIT_C1321 inSubset NCIT_C116978 @default.
- NCIT_C1321 inSubset NCIT_C176424 @default.
- NCIT_C1321 inSubset NCIT_C63923 @default.
- NCIT_C1321 type Class @default.
- NCIT_C1321 isDefinedBy ncit.owl @default.
- NCIT_C1321 label "Muromonab-CD3" @default.
- NCIT_C1321 subClassOf NCIT_C112883 @default.
- NCIT_C1321 subClassOf NCIT_C1321 @default.
- NCIT_C1321 subClassOf NCIT_C1908 @default.
- NCIT_C1321 subClassOf NCIT_C1909 @default.
- NCIT_C1321 subClassOf NCIT_C20401 @default.
- NCIT_C1321 subClassOf NCIT_C307 @default.
- NCIT_C1321 subClassOf NCIT_C308 @default.