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- NCIT_C132112 IAO_0000115 "An antibody-drug conjugate (ADC) composed of HT-19, a monoclonal antibody directed against the human epidermal growth factor receptor 2 (ERBB2; HER2), conjugated, via a proprietary biodegradable, hydrophilic polymer backbone and various linkers, to proprietary auristatin-derived payload molecules (about 15 per antibody), with potential antineoplastic activity. Upon administration of anti-HER2/auristatin payload ADC XMT-1522, the antibody moiety targets and binds to a unique epitope in the extracellular domain (ECD) of HER2. Upon internalization, cleavage and release of the cytotoxic molecules, the auristatin-derived molecules bind to tubulin and inhibit its polymerization, which results in G2/M phase arrest and induces apoptosis of HER2-expressing tumor cells. The attachment of multiple auristatin molecules to the backbone enables XMT-1522 to effectively kill tumors that express relatively low amounts of the HER2 protein; therefore, this agent shows increased therapeutic potential in tumors with low HER2 expression compared to other anti-HER2 antibody-based therapies. The polymer-based proprietary platform optimizes delivery of the cytotoxic drug payload and improves drug solubility." @default.
- NCIT_C132112 NCIT_A32 NCIT_C1909 @default.
- NCIT_C132112 NCIT_A7 NCIT_C17319 @default.
- NCIT_C132112 NCIT_NHC0 "C132112" @default.
- NCIT_C132112 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132112 NCIT_P107 "Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522" @default.
- NCIT_C132112 NCIT_P108 "Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522" @default.
- NCIT_C132112 NCIT_P208 "CL520319" @default.
- NCIT_C132112 NCIT_P322 "CTRP" @default.
- NCIT_C132112 NCIT_P322 "GDC" @default.
- NCIT_C132112 NCIT_P329 "786937" @default.
- NCIT_C132112 NCIT_P330 "786937" @default.
- NCIT_C132112 NCIT_P375 "Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522" @default.
- NCIT_C132112 NCIT_P399 "786937" @default.
- NCIT_C132112 normalizedInformationContent "100" @default.
- NCIT_C132112 referenceCount "1" @default.
- NCIT_C132112 hasExactSynonym "ADC XMT-1522" @default.
- NCIT_C132112 hasExactSynonym "Anti-HER2 ADC XMT-1522" @default.
- NCIT_C132112 hasExactSynonym "Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522" @default.
- NCIT_C132112 hasExactSynonym "XMT-1522" @default.
- NCIT_C132112 inSubset NCIT_C116977 @default.
- NCIT_C132112 inSubset NCIT_C116978 @default.
- NCIT_C132112 inSubset NCIT_C128784 @default.
- NCIT_C132112 inSubset NCIT_C157711 @default.
- NCIT_C132112 inSubset NCIT_C157712 @default.
- NCIT_C132112 inSubset NCIT_C176424 @default.
- NCIT_C132112 inSubset NCIT_C177537 @default.
- NCIT_C132112 type Class @default.
- NCIT_C132112 isDefinedBy ncit.owl @default.
- NCIT_C132112 label "Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522" @default.
- NCIT_C132112 subClassOf NCIT_C129821 @default.
- NCIT_C132112 subClassOf NCIT_C129823 @default.
- NCIT_C132112 subClassOf NCIT_C132112 @default.
- NCIT_C132112 subClassOf NCIT_C1512 @default.
- NCIT_C132112 subClassOf NCIT_C155712 @default.
- NCIT_C132112 subClassOf NCIT_C163758 @default.
- NCIT_C132112 subClassOf NCIT_C163760 @default.
- NCIT_C132112 subClassOf NCIT_C1908 @default.
- NCIT_C132112 subClassOf NCIT_C1909 @default.
- NCIT_C132112 subClassOf NCIT_C274 @default.
- NCIT_C132112 subClassOf NCIT_C307 @default.
- NCIT_C132112 subClassOf NCIT_C308 @default.