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- NCIT_C132257 IAO_0000115 "A proprietary, suppository-based formulation composed of idronoxil, a synthetic flavonoid derivative, surrounded by a proprietary lipid that protects idronoxil from phase 2 degradation, with potential chemo- and radio-sensitizing activities. Upon administration, idronoxil blocks the activity of ecto-NOX disulfide-thiol exchanger 2 (ENOX2; tNOX), a tumor-specific external NADH oxidase that maintains the transmembrane electron potential across the plasma membrane and is overexpressed in certain cancer cell types while absent in normal, healthy cells. Loss of this potential directly inhibits certain pro-survival signal transduction pathways, such as the PARP1/PI3 kinase/Akt signaling pathway. The inhibition of these pathways prevents resistance to standard chemo- and radio-therapy and makes tumor cells more susceptible to the anti-tumor activity of conventional chemotherapeutic agents and radiotherapy. The formulation prevents detoxification of idronoxil to an inactive form by bypassing phase 2 metabolism; this increases idronoxil's bioavailability as compared to idronoxil alone." @default.
- NCIT_C132257 NCIT_A32 NCIT_C1909 @default.
- NCIT_C132257 NCIT_NHC0 "C132257" @default.
- NCIT_C132257 NCIT_P106 "Organic Chemical" @default.
- NCIT_C132257 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132257 NCIT_P107 "Idronoxil Suppository NOX66" @default.
- NCIT_C132257 NCIT_P108 "Idronoxil Suppository NOX66" @default.
- NCIT_C132257 NCIT_P208 "CL520045" @default.
- NCIT_C132257 NCIT_P322 "CTRP" @default.
- NCIT_C132257 NCIT_P322 "GDC" @default.
- NCIT_C132257 NCIT_P329 "787307" @default.
- NCIT_C132257 NCIT_P330 "787307" @default.
- NCIT_C132257 NCIT_P375 "Idronoxil Suppository NOX66" @default.
- NCIT_C132257 NCIT_P399 "787307" @default.
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- NCIT_C132257 normalizedInformationContent "100" @default.
- NCIT_C132257 referenceCount "1" @default.
- NCIT_C132257 hasExactSynonym "Idronoxil Suppository NOX66" @default.
- NCIT_C132257 hasExactSynonym "NOX66" @default.
- NCIT_C132257 inSubset NCIT_C116977 @default.
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- NCIT_C132257 inSubset NCIT_C177537 @default.
- NCIT_C132257 type Class @default.
- NCIT_C132257 isDefinedBy ncit.owl @default.
- NCIT_C132257 label "Idronoxil Suppository NOX66" @default.
- NCIT_C132257 subClassOf B3d00b14df8290d2a43ec506a35836919 @default.
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- NCIT_C132257 subClassOf Bc074f3d2a12e134a0fa7014fc8740bc2 @default.
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- NCIT_C132257 subClassOf NCIT_C132257 @default.
- NCIT_C132257 subClassOf NCIT_C1908 @default.
- NCIT_C132257 subClassOf NCIT_C1909 @default.
- NCIT_C132257 subClassOf NCIT_C2189 @default.
- NCIT_C132257 subClassOf NCIT_C274 @default.
- NCIT_C132257 subClassOf NCIT_C471 @default.