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- NCIT_C132277 IAO_0000115 "A synthetic decapeptide and antagonist of the naturally occurring gonadotropin-releasing hormone (GnRH), with potential hormone production inhibitory and antineoplastic activities. Upon administration, teverelix directly competes with GnRH for receptor binding in the anterior pituitary gland, thereby inhibiting GnRH receptor signaling. This inhibits the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation. In females, this prevents the production of estrogen by the ovaries and may relieve symptoms from sex-hormone dependent diseases." @default.
- NCIT_C132277 NCIT_A7 NCIT_C38910 @default.
- NCIT_C132277 NCIT_NHC0 "C132277" @default.
- NCIT_C132277 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132277 NCIT_P108 "Teverelix" @default.
- NCIT_C132277 NCIT_P207 "C0249057" @default.
- NCIT_C132277 NCIT_P210 "151272-78-5" @default.
- NCIT_C132277 NCIT_P319 "D19V7048JK" @default.
- NCIT_C132277 NCIT_P322 "FDA" @default.
- NCIT_C132277 normalizedInformationContent "100" @default.
- NCIT_C132277 referenceCount "1" @default.
- NCIT_C132277 hasExactSynonym "ANB019" @default.
- NCIT_C132277 hasExactSynonym "Ac-D-Nal-D-cpa-D-pal-ser-tyr-D-hci-leu-lys(ipr)-pro-D-ala-NH2" @default.
- NCIT_C132277 hasExactSynonym "D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-(aminocarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-" @default.
- NCIT_C132277 hasExactSynonym "EP 24332" @default.
- NCIT_C132277 hasExactSynonym "TEVERELIX" @default.
- NCIT_C132277 hasExactSynonym "Teverelix" @default.
- NCIT_C132277 inSubset NCIT_C128784 @default.
- NCIT_C132277 inSubset NCIT_C63923 @default.
- NCIT_C132277 type Class @default.
- NCIT_C132277 isDefinedBy ncit.owl @default.
- NCIT_C132277 label "Teverelix" @default.
- NCIT_C132277 subClassOf NCIT_C132277 @default.
- NCIT_C132277 subClassOf NCIT_C147908 @default.
- NCIT_C132277 subClassOf NCIT_C1908 @default.
- NCIT_C132277 subClassOf NCIT_C1909 @default.
- NCIT_C132277 subClassOf NCIT_C2092 @default.
- NCIT_C132277 subClassOf NCIT_C547 @default.