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- NCIT_C1326 IAO_0000115 "The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects." @default.
- NCIT_C1326 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1326 NCIT_A6 NCIT_C456 @default.
- NCIT_C1326 NCIT_NHC0 "C1326" @default.
- NCIT_C1326 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1326 NCIT_P107 "Doxorubicin Hydrochloride" @default.
- NCIT_C1326 NCIT_P108 "Doxorubicin Hydrochloride" @default.
- NCIT_C1326 NCIT_P175 "123127" @default.
- NCIT_C1326 NCIT_P207 "C0546861" @default.
- NCIT_C1326 NCIT_P210 "25316-40-9" @default.
- NCIT_C1326 NCIT_P302 "Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Wilms' tumor; neuroblastoma; soft tissue and bone sarcomas; small cell carcinoma of the lung; lymphomas; multiple myeloma; mesotheliomas; germ cell tumors of the ovary or testis." @default.
- NCIT_C1326 NCIT_P302 "Carcinomas of breast, thyroid, gastric, ovarian, bronchogenic, head and neck, prostate, cervical, pancreatic, uterine, hepatic, and transitional cell bladder carcinomas." @default.
- NCIT_C1326 NCIT_P319 "82F2G7BL4E" @default.
- NCIT_C1326 NCIT_P322 "CTRP" @default.
- NCIT_C1326 NCIT_P322 "FDA" @default.
- NCIT_C1326 NCIT_P322 "GDC" @default.
- NCIT_C1326 NCIT_P322 "PCDC" @default.
- NCIT_C1326 NCIT_P325 "A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic." @default.
- NCIT_C1326 NCIT_P329 "38860" @default.
- NCIT_C1326 NCIT_P330 "38860" @default.
- NCIT_C1326 NCIT_P350 "C27H29NO11.HCl" @default.
- NCIT_C1326 NCIT_P366 "Doxorubicin_Hydrochloride" @default.
- NCIT_C1326 NCIT_P375 "Doxorubicin Hydrochloride" @default.
- NCIT_C1326 NCIT_P399 "38860" @default.
- NCIT_C1326 normalizedInformationContent "70.840024271697999" @default.
- NCIT_C1326 referenceCount "82" @default.
- NCIT_C1326 hasExactSynonym "14-Hydroxydaunorubicin Hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "3-Hydroxyacetyldaunorubicin Hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)" @default.
- NCIT_C1326 hasExactSynonym "5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-(9CI)" @default.
- NCIT_C1326 hasExactSynonym "ADM" @default.
- NCIT_C1326 hasExactSynonym "ADRIAMYCIN, HYDROCHLORIDE" @default.
- NCIT_C1326 hasExactSynonym "Adriacin" @default.
- NCIT_C1326 hasExactSynonym "Adriamycin Hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "Adriamycin PFS" @default.
- NCIT_C1326 hasExactSynonym "Adriamycin RDF" @default.
- NCIT_C1326 hasExactSynonym "Adriamycin hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "Adriamycin" @default.
- NCIT_C1326 hasExactSynonym "Adriamycine" @default.
- NCIT_C1326 hasExactSynonym "Adriblastina" @default.
- NCIT_C1326 hasExactSynonym "Adriblastine" @default.
- NCIT_C1326 hasExactSynonym "Adrimedac" @default.
- NCIT_C1326 hasExactSynonym "Chloridrato de Doxorrubicina" @default.
- NCIT_C1326 hasExactSynonym "DOX" @default.
- NCIT_C1326 hasExactSynonym "DOXO-CELL" @default.
- NCIT_C1326 hasExactSynonym "DOXORUBICIN HYDROCHLORIDE" @default.
- NCIT_C1326 hasExactSynonym "Doxolem" @default.
- NCIT_C1326 hasExactSynonym "Doxorubicin HCl" @default.
- NCIT_C1326 hasExactSynonym "Doxorubicin Hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "Doxorubicin hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "Doxorubicin.HCl" @default.
- NCIT_C1326 hasExactSynonym "Doxorubin" @default.
- NCIT_C1326 hasExactSynonym "FI 106" @default.
- NCIT_C1326 hasExactSynonym "FI-106" @default.
- NCIT_C1326 hasExactSynonym "Farmiblastina" @default.
- NCIT_C1326 hasExactSynonym "L-Lyxo-hexopyranoside, 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-, hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "Rubex" @default.
- NCIT_C1326 hasExactSynonym "doxorubicin hydrochloride" @default.
- NCIT_C1326 hasExactSynonym "hydroxydaunorubicin" @default.
- NCIT_C1326 inSubset NCIT_C116977 @default.
- NCIT_C1326 inSubset NCIT_C116978 @default.
- NCIT_C1326 inSubset NCIT_C128784 @default.
- NCIT_C1326 inSubset NCIT_C157711 @default.
- NCIT_C1326 inSubset NCIT_C157712 @default.
- NCIT_C1326 inSubset NCIT_C176424 @default.
- NCIT_C1326 inSubset NCIT_C177537 @default.
- NCIT_C1326 inSubset NCIT_C179484 @default.
- NCIT_C1326 inSubset NCIT_C63923 @default.
- NCIT_C1326 type Class @default.
- NCIT_C1326 isDefinedBy ncit.owl @default.
- NCIT_C1326 label "Doxorubicin Hydrochloride" @default.
- NCIT_C1326 subClassOf NCIT_C129824 @default.
- NCIT_C1326 subClassOf NCIT_C129825 @default.
- NCIT_C1326 subClassOf NCIT_C1326 @default.
- NCIT_C1326 subClassOf NCIT_C1594 @default.
- NCIT_C1326 subClassOf NCIT_C1748 @default.
- NCIT_C1326 subClassOf NCIT_C186664 @default.
- NCIT_C1326 subClassOf NCIT_C1908 @default.
- NCIT_C1326 subClassOf NCIT_C1909 @default.
- NCIT_C1326 subClassOf NCIT_C1968 @default.
- NCIT_C1326 subClassOf NCIT_C2115 @default.
- NCIT_C1326 subClassOf NCIT_C2161 @default.
- NCIT_C1326 subClassOf NCIT_C2189 @default.
- NCIT_C1326 subClassOf NCIT_C259 @default.
- NCIT_C1326 subClassOf NCIT_C274 @default.
- NCIT_C1326 subClassOf NCIT_C2842 @default.
- NCIT_C1326 subClassOf NCIT_C471 @default.
- NCIT_C1326 subClassOf NCIT_C67502 @default.