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- NCIT_C132684 IAO_0000115 "A vaccine composed of a peptide derived from histone H3.3 containing the amino acid substitution mutation lysine (Lys) 27-to-methionine (H3.3K27M), with potential immunoactivating and antineoplastic activities. Upon administration of the H3.3K27M-specific peptide vaccine, the immune system may exert a cytotoxic T-lymphocyte (CTL)-mediated immune response against H3.3K27M-expressing tumor cells. The H3.3K27M mutation alters the methylation and acetylation profile of the histone H3 variant H3.3 at Lys 27. Modification of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a variety of cancer cell types." @default.
- NCIT_C132684 NCIT_A7 NCIT_C148096 @default.
- NCIT_C132684 NCIT_NHC0 "C132684" @default.
- NCIT_C132684 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C132684 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132684 NCIT_P107 "H3.3K27M-specific Peptide Vaccine" @default.
- NCIT_C132684 NCIT_P108 "H3.3K27M-specific Peptide Vaccine" @default.
- NCIT_C132684 NCIT_P208 "CL519856" @default.
- NCIT_C132684 NCIT_P322 "CTRP" @default.
- NCIT_C132684 NCIT_P329 "787126" @default.
- NCIT_C132684 NCIT_P330 "787126" @default.
- NCIT_C132684 NCIT_P399 "787126" @default.
- NCIT_C132684 normalizedInformationContent "100" @default.
- NCIT_C132684 referenceCount "1" @default.
- NCIT_C132684 hasExactSynonym "H3.3K27M Peptide Vaccine" @default.
- NCIT_C132684 hasExactSynonym "H3.3K27M-specific Peptide Vaccine" @default.
- NCIT_C132684 inSubset NCIT_C116977 @default.
- NCIT_C132684 inSubset NCIT_C116978 @default.
- NCIT_C132684 inSubset NCIT_C128784 @default.
- NCIT_C132684 inSubset NCIT_C176424 @default.
- NCIT_C132684 type Class @default.
- NCIT_C132684 isDefinedBy ncit.owl @default.
- NCIT_C132684 label "H3.3K27M-specific Peptide Vaccine" @default.
- NCIT_C132684 subClassOf NCIT_C129820 @default.
- NCIT_C132684 subClassOf NCIT_C132684 @default.
- NCIT_C132684 subClassOf NCIT_C1663 @default.
- NCIT_C132684 subClassOf NCIT_C1908 @default.
- NCIT_C132684 subClassOf NCIT_C1909 @default.
- NCIT_C132684 subClassOf NCIT_C274 @default.
- NCIT_C132684 subClassOf NCIT_C307 @default.
- NCIT_C132684 subClassOf NCIT_C308 @default.
- NCIT_C132684 subClassOf NCIT_C923 @default.