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- NCIT_C132989 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation." @default.
- NCIT_C132989 NCIT_NHC0 "C132989" @default.
- NCIT_C132989 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C132989 NCIT_P107 "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes" @default.
- NCIT_C132989 NCIT_P108 "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes" @default.
- NCIT_C132989 NCIT_P208 "CL520573" @default.
- NCIT_C132989 NCIT_P322 "CTRP" @default.
- NCIT_C132989 NCIT_P329 "787596" @default.
- NCIT_C132989 NCIT_P330 "787596" @default.
- NCIT_C132989 NCIT_P399 "787596" @default.
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- NCIT_C132989 NCIT_R72 NCIT_C39567 @default.
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- NCIT_C132989 normalizedInformationContent "100" @default.
- NCIT_C132989 referenceCount "1" @default.
- NCIT_C132989 hasExactSynonym "Anti-GPC3-scFvGC33-CAR Autologous T Lymphocytes" @default.
- NCIT_C132989 hasExactSynonym "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes" @default.
- NCIT_C132989 hasExactSynonym "Autologous GAP T Cells" @default.
- NCIT_C132989 hasExactSynonym "Autologous GPC3-CAR T Cells" @default.
- NCIT_C132989 hasExactSynonym "GPC3-CAR Transduced Autologous T Cells" @default.
- NCIT_C132989 hasExactSynonym "Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells" @default.
- NCIT_C132989 hasExactSynonym "Glypican 3-specific Chimeric Antigen Receptor-expressing Autologous T Cells" @default.
- NCIT_C132989 inSubset NCIT_C116977 @default.
- NCIT_C132989 inSubset NCIT_C116978 @default.
- NCIT_C132989 inSubset NCIT_C128784 @default.
- NCIT_C132989 inSubset NCIT_C176424 @default.
- NCIT_C132989 type Class @default.
- NCIT_C132989 isDefinedBy ncit.owl @default.
- NCIT_C132989 label "Anti-Glypican 3-scFvGC33-CAR-expressing T Lymphocytes" @default.
- NCIT_C132989 subClassOf NCIT_C129820 @default.
- NCIT_C132989 subClassOf NCIT_C129821 @default.
- NCIT_C132989 subClassOf NCIT_C129826 @default.
- NCIT_C132989 subClassOf NCIT_C132989 @default.
- NCIT_C132989 subClassOf NCIT_C137999 @default.
- NCIT_C132989 subClassOf NCIT_C142078 @default.
- NCIT_C132989 subClassOf NCIT_C154231 @default.
- NCIT_C132989 subClassOf NCIT_C1908 @default.
- NCIT_C132989 subClassOf NCIT_C1909 @default.
- NCIT_C132989 subClassOf NCIT_C1962 @default.
- NCIT_C132989 subClassOf NCIT_C200766 @default.
- NCIT_C132989 subClassOf NCIT_C274 @default.
- NCIT_C132989 subClassOf NCIT_C28681 @default.
- NCIT_C132989 subClassOf NCIT_C307 @default.
- NCIT_C132989 subClassOf NCIT_C308 @default.