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- NCIT_C133020 IAO_0000115 "An orally bioavailable form of the element gallium (Ga) composed of a trivalent gallium cation (Ga3+) coordinated to three maltolate ligands, with anti-inflammatory, anti-proliferative, antineoplastic, analgesic, antiresorptive and antibacterial activities. Upon administration of gallium maltolate, Ga3+, which is structurally similar to the ferric ion (Fe3+), competes with and replaces Fe3+ in many vital Fe 3+-mediated biological reactions.. Unlike Fe3+, Ga3+ cannot be reduced, cannot participate in redox reactions and cannot mimic Fe3+ functions. In rapidly proliferating cells, such as cancer cells, high amounts of iron are needed for DNA synthesis. The incorporation of Ga3+ inactivates the Fe3+-dependent enzyme ribonucleotide reductase (RR), an enzyme essential for DNA synthesis, leading to an inhibition of DNA synthesis and induction of cell death in rapidly proliferating cells. Gallium similarly reduces bacterial cell growth. In addition, Ga3+ is able to suppress inflammation through the down-regulation of pro-inflammatory cells and the inhibition of pro-inflammatory cytokine secretion. Gallium also exerts analgesic effects due to the inhibition of Fe3+-dependent enzymes involved in inflammation and may interfere with the activity of certain metalloproteinases and neuropeptides that are implicated in pain. Also, gallium is able to inhibit bone resorption by osteoclasts, may inhibit metastasis to bone and may prevent the destruction of bone by tumors." @default.
- NCIT_C133020 NCIT_NHC0 "C133020" @default.
- NCIT_C133020 NCIT_P106 "Organic Chemical" @default.
- NCIT_C133020 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133020 NCIT_P108 "Gallium Maltolate" @default.
- NCIT_C133020 NCIT_P207 "C1328202" @default.
- NCIT_C133020 NCIT_P210 "108560-70-9" @default.
- NCIT_C133020 NCIT_P319 "17LEI49C2G" @default.
- NCIT_C133020 NCIT_P322 "FDA" @default.
- NCIT_C133020 NCIT_P329 "355806" @default.
- NCIT_C133020 NCIT_P330 "355806" @default.
- NCIT_C133020 NCIT_P399 "355806" @default.
- NCIT_C133020 NCIT_R124 NCIT_C17710 @default.
- NCIT_C133020 NCIT_R124 NCIT_C17828 @default.
- NCIT_C133020 NCIT_R124 NCIT_C19986 @default.
- NCIT_C133020 NCIT_R124 NCIT_C40551 @default.
- NCIT_C133020 NCIT_R125 NCIT_C17828 @default.
- NCIT_C133020 NCIT_R125 NCIT_C20150 @default.
- NCIT_C133020 NCIT_R125 NCIT_C20480 @default.
- NCIT_C133020 NCIT_R125 NCIT_C40715 @default.
- NCIT_C133020 NCIT_R125 NCIT_C41515 @default.
- NCIT_C133020 NCIT_R125 NCIT_C51037 @default.
- NCIT_C133020 normalizedInformationContent "100" @default.
- NCIT_C133020 referenceCount "1" @default.
- NCIT_C133020 hasExactSynonym "GALLIUM MALTOLATE" @default.
- NCIT_C133020 hasExactSynonym "GaM" @default.
- NCIT_C133020 hasExactSynonym "Gallium Maltolate" @default.
- NCIT_C133020 hasExactSynonym "Tris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium(III)" @default.
- NCIT_C133020 inSubset NCIT_C176424 @default.
- NCIT_C133020 inSubset NCIT_C63923 @default.
- NCIT_C133020 type Class @default.
- NCIT_C133020 isDefinedBy ncit.owl @default.
- NCIT_C133020 label "Gallium Maltolate" @default.
- NCIT_C133020 subClassOf B0e7725540d1e51459e8a04b8cf7d7fbc @default.
- NCIT_C133020 subClassOf B1d46400d2af934c0df29380bba6fe0b1 @default.
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- NCIT_C133020 subClassOf NCIT_C133020 @default.
- NCIT_C133020 subClassOf NCIT_C1908 @default.
- NCIT_C133020 subClassOf NCIT_C1909 @default.
- NCIT_C133020 subClassOf NCIT_C2136 @default.
- NCIT_C133020 subClassOf NCIT_C2150 @default.
- NCIT_C133020 subClassOf NCIT_C471 @default.
- NCIT_C133020 subClassOf NCIT_C67439 @default.
- NCIT_C133020 subClassOf NCIT_C78275 @default.
- NCIT_C133020 subClassOf NCIT_C78281 @default.