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- NCIT_C133021 IAO_0000115 "A class I ribosome-inactivating protein (RIP) and toxin derived from the seeds of the plant Gelonium multiflorum. Gelonin (rGel) exerts N-glycosidase activity on the 28S ribosomal RNA (rRNA) unit of eukaryotic ribosomes by cleaving out adenine at the 4324 site, which depurinates rRNA, inactivates ribosomes, inhibits protein synthesis, and results in cell death. Used as the toxin moiety of certain immunotoxins and linked to antibodies specific for a tumor-associated antigen (TAA), gelonin can be targeted to and induce specific cytotoxicity in tumor cells expressing the TAA." @default.
- NCIT_C133021 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133021 NCIT_NHC0 "C133021" @default.
- NCIT_C133021 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133021 NCIT_P108 "Gelonin" @default.
- NCIT_C133021 NCIT_P207 "C0061184" @default.
- NCIT_C133021 NCIT_P210 "75037-46-6" @default.
- NCIT_C133021 NCIT_P322 "GDC" @default.
- NCIT_C133021 NCIT_P329 "357568" @default.
- NCIT_C133021 NCIT_P330 "357568" @default.
- NCIT_C133021 NCIT_P375 "Gelonin" @default.
- NCIT_C133021 NCIT_P399 "357568" @default.
- NCIT_C133021 normalizedInformationContent "100" @default.
- NCIT_C133021 referenceCount "1" @default.
- NCIT_C133021 hasExactSynonym "GEL Protein, Gelonium multiflorum" @default.
- NCIT_C133021 hasExactSynonym "Gelonin" @default.
- NCIT_C133021 hasExactSynonym "LGK974" @default.
- NCIT_C133021 hasExactSynonym "Ribosome-inactivating Protein Gelonin, Gelonium multiflorum" @default.
- NCIT_C133021 hasExactSynonym "rGel" @default.
- NCIT_C133021 inSubset NCIT_C128784 @default.
- NCIT_C133021 inSubset NCIT_C157711 @default.
- NCIT_C133021 inSubset NCIT_C157712 @default.
- NCIT_C133021 inSubset NCIT_C176424 @default.
- NCIT_C133021 inSubset NCIT_C177537 @default.
- NCIT_C133021 type Class @default.
- NCIT_C133021 isDefinedBy ncit.owl @default.
- NCIT_C133021 label "Gelonin" @default.
- NCIT_C133021 subClassOf NCIT_C133021 @default.
- NCIT_C133021 subClassOf NCIT_C1908 @default.
- NCIT_C133021 subClassOf NCIT_C1909 @default.
- NCIT_C133021 subClassOf NCIT_C471 @default.