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- NCIT_C133072 IAO_0000115 "A preparation of genetically modified central memory (Tcm) enriched T-cells transduced with a replication incompetent lentiviral vector expressing a chimeric antigen receptor (CAR), containing a CD28 signaling domain fused to both CD3 zeta, which targets the CD19 antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. The costimulatory signaling domain enhances proliferation of T cells and antitumor activity." @default.
- NCIT_C133072 NCIT_A7 NCIT_C38894 @default.
- NCIT_C133072 NCIT_NHC0 "C133072" @default.
- NCIT_C133072 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133072 NCIT_P107 "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C133072 NCIT_P108 "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C133072 NCIT_P208 "CL519703" @default.
- NCIT_C133072 NCIT_P322 "CTRP" @default.
- NCIT_C133072 NCIT_P329 "788141" @default.
- NCIT_C133072 NCIT_P330 "788141" @default.
- NCIT_C133072 NCIT_P399 "788141" @default.
- NCIT_C133072 normalizedInformationContent "100" @default.
- NCIT_C133072 referenceCount "1" @default.
- NCIT_C133072 hasExactSynonym "CD19-CAR-specific/truncated EGFR Lentiviral Vector-transduced T Cells" @default.
- NCIT_C133072 hasExactSynonym "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T Cells" @default.
- NCIT_C133072 hasExactSynonym "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C133072 hasExactSynonym "CD19R(EQ)28zeta/EGFRt+ TCM" @default.
- NCIT_C133072 hasExactSynonym "CD19R(EQ)28zeta/truncated Human EGFR+ Central Memory T Cells" @default.
- NCIT_C133072 hasExactSynonym "CD19R:CD28:lentiviral/EGFRt+ T Cells" @default.
- NCIT_C133072 inSubset NCIT_C116977 @default.
- NCIT_C133072 inSubset NCIT_C116978 @default.
- NCIT_C133072 inSubset NCIT_C128784 @default.
- NCIT_C133072 inSubset NCIT_C176424 @default.
- NCIT_C133072 type Class @default.
- NCIT_C133072 isDefinedBy ncit.owl @default.
- NCIT_C133072 label "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes" @default.
- NCIT_C133072 subClassOf NCIT_C129820 @default.
- NCIT_C133072 subClassOf NCIT_C129821 @default.
- NCIT_C133072 subClassOf NCIT_C129826 @default.
- NCIT_C133072 subClassOf NCIT_C133072 @default.
- NCIT_C133072 subClassOf NCIT_C137999 @default.
- NCIT_C133072 subClassOf NCIT_C142078 @default.
- NCIT_C133072 subClassOf NCIT_C154231 @default.
- NCIT_C133072 subClassOf NCIT_C176018 @default.
- NCIT_C133072 subClassOf NCIT_C1908 @default.
- NCIT_C133072 subClassOf NCIT_C1909 @default.
- NCIT_C133072 subClassOf NCIT_C1962 @default.
- NCIT_C133072 subClassOf NCIT_C274 @default.
- NCIT_C133072 subClassOf NCIT_C307 @default.
- NCIT_C133072 subClassOf NCIT_C308 @default.