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- NCIT_C133073 IAO_0000115 "A preparation of genetically modified lymphocytes comprised of CD62L-positive naïve and memory T-cells (Tn/mem), that are transduced ex vivo with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) specific for the CD19 antigen and containing CD28 and CD3 zeta signaling domains, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon isolation of peripheral blood lymphocytes (PBLs), transduction of the CD62L-positive T-lymphocytes, expansion ex vivo and administration, the CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-cells target CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of the administered T-cells and can promote elimination of those cells upon a cetuximab-induced antibody dependent cellular cytotoxicity response. Tn/mem T-cells include naïve T-cells, central memory T-cells (Tcm) and stem cell memory T-cells (Tscm). CD19R(EQ) contains two point mutations in the immunoglobulin (Ig) G4 spacer region, thereby preventing recognition of the CAR by Fc receptors (FcRs)." @default.
- NCIT_C133073 NCIT_A7 NCIT_C38894 @default.
- NCIT_C133073 NCIT_NHC0 "C133073" @default.
- NCIT_C133073 NCIT_P106 "Cell" @default.
- NCIT_C133073 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133073 NCIT_P107 "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes" @default.
- NCIT_C133073 NCIT_P108 "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes" @default.
- NCIT_C133073 NCIT_P208 "CL519704" @default.
- NCIT_C133073 NCIT_P322 "CTRP" @default.
- NCIT_C133073 NCIT_P329 "788142" @default.
- NCIT_C133073 NCIT_P330 "788142" @default.
- NCIT_C133073 NCIT_P399 "788142" @default.
- NCIT_C133073 normalizedInformationContent "100" @default.
- NCIT_C133073 referenceCount "1" @default.
- NCIT_C133073 hasExactSynonym "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T Cells" @default.
- NCIT_C133073 hasExactSynonym "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes" @default.
- NCIT_C133073 hasExactSynonym "CD19R(EQ)28zeta/EGFRt+ Naive and Memory T Cells" @default.
- NCIT_C133073 hasExactSynonym "CD19R(EQ)28zetaEGFRt+ Tn/mem Cells" @default.
- NCIT_C133073 inSubset NCIT_C116977 @default.
- NCIT_C133073 inSubset NCIT_C116978 @default.
- NCIT_C133073 inSubset NCIT_C128784 @default.
- NCIT_C133073 inSubset NCIT_C176424 @default.
- NCIT_C133073 type Class @default.
- NCIT_C133073 isDefinedBy ncit.owl @default.
- NCIT_C133073 label "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes" @default.
- NCIT_C133073 subClassOf NCIT_C129820 @default.
- NCIT_C133073 subClassOf NCIT_C129821 @default.
- NCIT_C133073 subClassOf NCIT_C129826 @default.
- NCIT_C133073 subClassOf NCIT_C133073 @default.
- NCIT_C133073 subClassOf NCIT_C137999 @default.
- NCIT_C133073 subClassOf NCIT_C142078 @default.
- NCIT_C133073 subClassOf NCIT_C154231 @default.
- NCIT_C133073 subClassOf NCIT_C176018 @default.
- NCIT_C133073 subClassOf NCIT_C1908 @default.
- NCIT_C133073 subClassOf NCIT_C1909 @default.
- NCIT_C133073 subClassOf NCIT_C1962 @default.
- NCIT_C133073 subClassOf NCIT_C274 @default.
- NCIT_C133073 subClassOf NCIT_C307 @default.
- NCIT_C133073 subClassOf NCIT_C308 @default.