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- NCIT_C133094 IAO_0000115 "A radiotracer composed of a 20 amino acid peptide derived from the GH loop of an envelope protein (VP1) of the foot-and-mouth disease virus (FMDV), where the N-terminal lysine has been substituted with arginine, conjugated with two polyethylene glycol units and radiolabeled with fluorine 18, for potential positron emission tomography (PET) imaging of alphaVbeta6 integrin expression. Upon administration, the arginine-glycine-aspartic acid (RGD) motif within the peptide moiety of the fluorine 18 F alphaVbeta6-binding peptide selectively binds to alphaVbeta6 integrin. During PET imaging, alphaVbeta6-expressing tumor cells can be visualized and the degree of tumor growth can be determined. AlphaVbeta6 integrin, a cell adhesion and signaling receptor, is upregulated in certain cancers and has been associated with proliferation, migration and invasion of tumor cells." @default.
- NCIT_C133094 NCIT_A7 NCIT_C124258 @default.
- NCIT_C133094 NCIT_NHC0 "C133094" @default.
- NCIT_C133094 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133094 NCIT_P107 "Fluorine F 18 alphaVbeta6-Binding Peptide" @default.
- NCIT_C133094 NCIT_P108 "Fluorine F 18 alphaVbeta6-Binding Peptide" @default.
- NCIT_C133094 NCIT_P208 "CL520657" @default.
- NCIT_C133094 NCIT_P322 "CTRP" @default.
- NCIT_C133094 NCIT_P329 "789304" @default.
- NCIT_C133094 NCIT_P330 "789304" @default.
- NCIT_C133094 NCIT_P399 "789304" @default.
- NCIT_C133094 normalizedInformationContent "100" @default.
- NCIT_C133094 referenceCount "1" @default.
- NCIT_C133094 hasExactSynonym "18F-aVb6-BP" @default.
- NCIT_C133094 hasExactSynonym "18F-alphaVbeta6-Binding Peptide" @default.
- NCIT_C133094 hasExactSynonym "18F-alphaVbeta6-Binding-Peptide" @default.
- NCIT_C133094 hasExactSynonym "Fluorine F 18 alphaVbeta6-Binding Peptide" @default.
- NCIT_C133094 hasExactSynonym "Fluorine F 18-alphaVbeta6-Binding-Peptide" @default.
- NCIT_C133094 inSubset NCIT_C116977 @default.
- NCIT_C133094 inSubset NCIT_C116978 @default.
- NCIT_C133094 inSubset NCIT_C176424 @default.
- NCIT_C133094 type Class @default.
- NCIT_C133094 isDefinedBy ncit.owl @default.
- NCIT_C133094 label "Fluorine F 18 alphaVbeta6-Binding Peptide" @default.
- NCIT_C133094 subClassOf NCIT_C133094 @default.
- NCIT_C133094 subClassOf NCIT_C1446 @default.
- NCIT_C133094 subClassOf NCIT_C1908 @default.
- NCIT_C133094 subClassOf NCIT_C1909 @default.
- NCIT_C133094 subClassOf NCIT_C2124 @default.