Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C13313> ?p ?o ?g. }
Showing items 1 to 23 of
23
with 100 items per page.
- NCIT_C13313 IAO_0000115 "In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)" @default.
- NCIT_C13313 NCIT_NHC0 "C13313" @default.
- NCIT_C13313 NCIT_P106 "Amino Acid Sequence" @default.
- NCIT_C13313 NCIT_P108 "Helix-Loop-Helix Domain" @default.
- NCIT_C13313 NCIT_P207 "C0206678" @default.
- NCIT_C13313 NCIT_P366 "Helix-Loop-Helix_Domain" @default.
- NCIT_C13313 normalizedInformationContent "68.602014802415724" @default.
- NCIT_C13313 referenceCount "115" @default.
- NCIT_C13313 hasExactSynonym "HLH Domain" @default.
- NCIT_C13313 hasExactSynonym "HLH Motif" @default.
- NCIT_C13313 hasExactSynonym "Helix-Loop-Helix Domain" @default.
- NCIT_C13313 hasExactSynonym "Helix-Loop-Helix Motif" @default.
- NCIT_C13313 type Class @default.
- NCIT_C13313 isDefinedBy ncit.owl @default.
- NCIT_C13313 label "Helix-Loop-Helix Domain" @default.
- NCIT_C13313 subClassOf NCIT_C12219 @default.
- NCIT_C13313 subClassOf NCIT_C13303 @default.
- NCIT_C13313 subClassOf NCIT_C13313 @default.
- NCIT_C13313 subClassOf NCIT_C13379 @default.
- NCIT_C13313 subClassOf NCIT_C13425 @default.
- NCIT_C13313 subClassOf NCIT_C13671 @default.
- NCIT_C13313 subClassOf NCIT_C14134 @default.
- NCIT_C13313 subClassOf NCIT_C21599 @default.