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- NCIT_C13314 IAO_0000115 "Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different peptidase activities. The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the degradation of ubiquitinated cellular proteins and certain non-ubiquitinated proteins. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD)." @default.
- NCIT_C13314 NCIT_NHC0 "C13314" @default.
- NCIT_C13314 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C13314 NCIT_P106 "Cell Component" @default.
- NCIT_C13314 NCIT_P106 "Enzyme" @default.
- NCIT_C13314 NCIT_P108 "Proteasome" @default.
- NCIT_C13314 NCIT_P208 "CL448735" @default.
- NCIT_C13314 NCIT_P366 "Proteasome" @default.
- NCIT_C13314 NCIT_R82 NCIT_C12219 @default.
- NCIT_C13314 NCIT_R82 NCIT_C12508 @default.
- NCIT_C13314 NCIT_R82 NCIT_C21599 @default.
- NCIT_C13314 normalizedInformationContent "79.853901415798049" @default.
- NCIT_C13314 referenceCount "21" @default.
- NCIT_C13314 hasExactSynonym "Proteasome" @default.
- NCIT_C13314 hasExactSynonym "Proteosome" @default.
- NCIT_C13314 type Class @default.
- NCIT_C13314 isDefinedBy ncit.owl @default.
- NCIT_C13314 label "Proteasome" @default.
- NCIT_C13314 subClassOf NCIT_C12219 @default.
- NCIT_C13314 subClassOf NCIT_C13282 @default.
- NCIT_C13314 subClassOf NCIT_C13314 @default.
- NCIT_C13314 subClassOf NCIT_C14135 @default.
- NCIT_C13314 subClassOf NCIT_C32221 @default.
- NCIT_C13314 subClassOf NCIT_C34070 @default.