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- NCIT_C133190 IAO_0000115 "A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MAb) BC8 where the lysine side groups have been conjugated with decaborate (closo-decaborate; B10) and labeled with astatine (At) 211, with potential immunotherapeutic activity. Astatine At 211 anti-CD45 monoclonal antibody BC8-B10 binds to CD45 antigen, a receptor protein-tyrosine phosphatase expressed on the surface of both normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, this agent may deliver a cytotoxic dose of alpha radiation. Additionally, the radiolabel can be leveraged to assay the biodistribution and/or pharmacokinetics (absorption, distribution, metabolism and excretion) for this agent. The use of B10 rather than other labeling methods increases the therapeutic efficacy while decreasing the toxicity of the radioconjugate." @default.
- NCIT_C133190 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133190 NCIT_A7 NCIT_C17282 @default.
- NCIT_C133190 NCIT_NHC0 "C133190" @default.
- NCIT_C133190 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C133190 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133190 NCIT_P107 "Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 NCIT_P108 "Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 NCIT_P208 "CL520581" @default.
- NCIT_C133190 NCIT_P319 "3BVH1ZF9JX" @default.
- NCIT_C133190 NCIT_P322 "CTRP" @default.
- NCIT_C133190 NCIT_P322 "FDA" @default.
- NCIT_C133190 NCIT_P322 "GDC" @default.
- NCIT_C133190 NCIT_P329 "789457" @default.
- NCIT_C133190 NCIT_P330 "789457" @default.
- NCIT_C133190 NCIT_P375 "Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 NCIT_P399 "789457" @default.
- NCIT_C133190 normalizedInformationContent "100" @default.
- NCIT_C133190 referenceCount "1" @default.
- NCIT_C133190 hasExactSynonym "APAMISTAMAB-B10-ASTATINE AT-211" @default.
- NCIT_C133190 hasExactSynonym "Astatine 211-Labeled Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 hasExactSynonym "Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 hasExactSynonym "Astatine At 211 MAb BC8-B10" @default.
- NCIT_C133190 hasExactSynonym "At 211 Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 hasExactSynonym "At 211 MAb BC8-B10" @default.
- NCIT_C133190 inSubset NCIT_C116977 @default.
- NCIT_C133190 inSubset NCIT_C116978 @default.
- NCIT_C133190 inSubset NCIT_C128784 @default.
- NCIT_C133190 inSubset NCIT_C157711 @default.
- NCIT_C133190 inSubset NCIT_C157712 @default.
- NCIT_C133190 inSubset NCIT_C176424 @default.
- NCIT_C133190 inSubset NCIT_C177537 @default.
- NCIT_C133190 inSubset NCIT_C63923 @default.
- NCIT_C133190 type Class @default.
- NCIT_C133190 isDefinedBy ncit.owl @default.
- NCIT_C133190 label "Astatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10" @default.
- NCIT_C133190 subClassOf NCIT_C129819 @default.
- NCIT_C133190 subClassOf NCIT_C133190 @default.
- NCIT_C133190 subClassOf NCIT_C1446 @default.
- NCIT_C133190 subClassOf NCIT_C1511 @default.
- NCIT_C133190 subClassOf NCIT_C1512 @default.
- NCIT_C133190 subClassOf NCIT_C1908 @default.
- NCIT_C133190 subClassOf NCIT_C1909 @default.
- NCIT_C133190 subClassOf NCIT_C200225 @default.
- NCIT_C133190 subClassOf NCIT_C2124 @default.
- NCIT_C133190 subClassOf NCIT_C274 @default.
- NCIT_C133190 subClassOf NCIT_C307 @default.
- NCIT_C133190 subClassOf NCIT_C308 @default.