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- NCIT_C133191 IAO_0000115 "A preparation of a defined ratio of CD4+ and bulk CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing a human anti-CD19 single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous human anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity." @default.
- NCIT_C133191 NCIT_NHC0 "C133191" @default.
- NCIT_C133191 NCIT_P106 "Cell" @default.
- NCIT_C133191 NCIT_P108 "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes" @default.
- NCIT_C133191 NCIT_P208 "CL520585" @default.
- NCIT_C133191 NCIT_P329 "788957" @default.
- NCIT_C133191 NCIT_P330 "788957" @default.
- NCIT_C133191 NCIT_P399 "788957" @default.
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- NCIT_C133191 NCIT_R72 NCIT_C104083 @default.
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- NCIT_C133191 normalizedInformationContent "100" @default.
- NCIT_C133191 referenceCount "1" @default.
- NCIT_C133191 hasExactSynonym "Anti-CD19-CAR Genetically Engineered Autologous T Lymphocytes huJCAR014" @default.
- NCIT_C133191 hasExactSynonym "Anti-CD19-CAR Genetically Engineered Autologous T-lymphocytes huJCAR014" @default.
- NCIT_C133191 hasExactSynonym "Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes" @default.
- NCIT_C133191 hasExactSynonym "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes" @default.
- NCIT_C133191 hasExactSynonym "huJCAR014" @default.
- NCIT_C133191 inSubset NCIT_C176424 @default.
- NCIT_C133191 type Class @default.
- NCIT_C133191 isDefinedBy ncit.owl @default.
- NCIT_C133191 label "Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes" @default.
- NCIT_C133191 subClassOf NCIT_C129820 @default.
- NCIT_C133191 subClassOf NCIT_C129821 @default.
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- NCIT_C133191 subClassOf NCIT_C133191 @default.
- NCIT_C133191 subClassOf NCIT_C137999 @default.
- NCIT_C133191 subClassOf NCIT_C142078 @default.
- NCIT_C133191 subClassOf NCIT_C154231 @default.
- NCIT_C133191 subClassOf NCIT_C176018 @default.
- NCIT_C133191 subClassOf NCIT_C1908 @default.
- NCIT_C133191 subClassOf NCIT_C1909 @default.
- NCIT_C133191 subClassOf NCIT_C1962 @default.
- NCIT_C133191 subClassOf NCIT_C200766 @default.
- NCIT_C133191 subClassOf NCIT_C274 @default.
- NCIT_C133191 subClassOf NCIT_C28681 @default.
- NCIT_C133191 subClassOf NCIT_C307 @default.
- NCIT_C133191 subClassOf NCIT_C308 @default.