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- NCIT_C133238 IAO_0000115 "An orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks." @default.
- NCIT_C133238 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133238 NCIT_A6 NCIT_C80059 @default.
- NCIT_C133238 NCIT_A7 NCIT_C104720 @default.
- NCIT_C133238 NCIT_A7 NCIT_C48215 @default.
- NCIT_C133238 NCIT_NHC0 "C133238" @default.
- NCIT_C133238 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133238 NCIT_P108 "Niraparib Tosylate Monohydrate" @default.
- NCIT_C133238 NCIT_P208 "CL520459" @default.
- NCIT_C133238 NCIT_P210 "1613220-15-7" @default.
- NCIT_C133238 NCIT_P302 "maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer" @default.
- NCIT_C133238 NCIT_P319 "195Q483UZD" @default.
- NCIT_C133238 NCIT_P322 "FDA" @default.
- NCIT_C133238 NCIT_P322 "GDC" @default.
- NCIT_C133238 NCIT_P329 "615263" @default.
- NCIT_C133238 NCIT_P330 "615263" @default.
- NCIT_C133238 NCIT_P375 "Niraparib Tosylate Monohydrate" @default.
- NCIT_C133238 NCIT_P399 "615263" @default.
- NCIT_C133238 NCIT_R146 NCIT_C104101 @default.
- NCIT_C133238 NCIT_R146 NCIT_C16554 @default.
- NCIT_C133238 NCIT_R146 NCIT_C17021 @default.
- NCIT_C133238 NCIT_R146 NCIT_C17210 @default.
- NCIT_C133238 NCIT_R146 NCIT_C17434 @default.
- NCIT_C133238 NCIT_R146 NCIT_C20027 @default.
- NCIT_C133238 NCIT_R146 NCIT_C21170 @default.
- NCIT_C133238 NCIT_R146 NCIT_C26548 @default.
- NCIT_C133238 NCIT_R146 NCIT_C48215 @default.
- NCIT_C133238 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C133238 referenceCount "3" @default.
- NCIT_C133238 hasExactSynonym "2H-Indazole-7-carboxamide, 2-(4-(3S)-3-piperidinylphenyl)-, 4-Methylbenzenesulfonate, Hydrate (1:1:1)" @default.
- NCIT_C133238 hasExactSynonym "NIRAPARIB TOSYLATE MONOHYDRATE" @default.
- NCIT_C133238 hasExactSynonym "Niraparib Tosylate Monohydrate" @default.
- NCIT_C133238 hasExactSynonym "Zejula" @default.
- NCIT_C133238 inSubset NCIT_C128784 @default.
- NCIT_C133238 inSubset NCIT_C157711 @default.
- NCIT_C133238 inSubset NCIT_C157712 @default.
- NCIT_C133238 inSubset NCIT_C176424 @default.
- NCIT_C133238 inSubset NCIT_C177537 @default.
- NCIT_C133238 inSubset NCIT_C63923 @default.
- NCIT_C133238 type Class @default.
- NCIT_C133238 isDefinedBy ncit.owl @default.
- NCIT_C133238 label "Niraparib Tosylate Monohydrate" @default.
- NCIT_C133238 subClassOf NCIT_C133238 @default.
- NCIT_C133238 subClassOf NCIT_C163758 @default.
- NCIT_C133238 subClassOf NCIT_C1908 @default.
- NCIT_C133238 subClassOf NCIT_C1909 @default.
- NCIT_C133238 subClassOf NCIT_C274 @default.
- NCIT_C133238 subClassOf NCIT_C471 @default.
- NCIT_C133238 subClassOf NCIT_C62554 @default.