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- NCIT_C133543 IAO_0000115 "A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties. Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes. P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells. Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC)." @default.
- NCIT_C133543 NCIT_A7 NCIT_C17522 @default.
- NCIT_C133543 NCIT_NHC0 "C133543" @default.
- NCIT_C133543 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133543 NCIT_P107 "Crizanlizumab" @default.
- NCIT_C133543 NCIT_P108 "Crizanlizumab" @default.
- NCIT_C133543 NCIT_P208 "CL519758" @default.
- NCIT_C133543 NCIT_P210 "1690318-25-2" @default.
- NCIT_C133543 NCIT_P319 "L7451S9126" @default.
- NCIT_C133543 NCIT_P322 "CTRP" @default.
- NCIT_C133543 NCIT_P322 "FDA" @default.
- NCIT_C133543 NCIT_P329 "788634" @default.
- NCIT_C133543 NCIT_P330 "788634" @default.
- NCIT_C133543 NCIT_P399 "788634" @default.
- NCIT_C133543 normalizedInformationContent "100" @default.
- NCIT_C133543 referenceCount "1" @default.
- NCIT_C133543 hasExactSynonym "Adakveo" @default.
- NCIT_C133543 hasExactSynonym "CRIZANLIZUMAB" @default.
- NCIT_C133543 hasExactSynonym "Crizanlizumab" @default.
- NCIT_C133543 hasExactSynonym "Crizanlizumab-tmca" @default.
- NCIT_C133543 hasExactSynonym "SEG101" @default.
- NCIT_C133543 hasExactSynonym "SelG1" @default.
- NCIT_C133543 inSubset NCIT_C116977 @default.
- NCIT_C133543 inSubset NCIT_C116978 @default.
- NCIT_C133543 inSubset NCIT_C173381 @default.
- NCIT_C133543 inSubset NCIT_C173383 @default.
- NCIT_C133543 inSubset NCIT_C176424 @default.
- NCIT_C133543 inSubset NCIT_C63923 @default.
- NCIT_C133543 type Class @default.
- NCIT_C133543 isDefinedBy ncit.owl @default.
- NCIT_C133543 label "Crizanlizumab" @default.
- NCIT_C133543 subClassOf NCIT_C133543 @default.
- NCIT_C133543 subClassOf NCIT_C1908 @default.
- NCIT_C133543 subClassOf NCIT_C1909 @default.
- NCIT_C133543 subClassOf NCIT_C78275 @default.