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- NCIT_C133691 IAO_0000115 "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, aumolertinib binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C133691 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133691 NCIT_A7 NCIT_C98503 @default.
- NCIT_C133691 NCIT_NHC0 "C133691" @default.
- NCIT_C133691 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133691 NCIT_P107 "Aumolertinib" @default.
- NCIT_C133691 NCIT_P108 "Aumolertinib" @default.
- NCIT_C133691 NCIT_P208 "CL521177" @default.
- NCIT_C133691 NCIT_P210 "1899921-05-1" @default.
- NCIT_C133691 NCIT_P319 "T4RS462G19" @default.
- NCIT_C133691 NCIT_P322 "CTRP" @default.
- NCIT_C133691 NCIT_P322 "FDA" @default.
- NCIT_C133691 NCIT_P322 "GDC" @default.
- NCIT_C133691 NCIT_P329 "788548" @default.
- NCIT_C133691 NCIT_P330 "788548" @default.
- NCIT_C133691 NCIT_P375 "EGFR T790M Inhibitor HS-10296" @default.
- NCIT_C133691 NCIT_P399 "788548" @default.
- NCIT_C133691 normalizedInformationContent "100" @default.
- NCIT_C133691 referenceCount "1" @default.
- NCIT_C133691 hasExactSynonym "AUMOLERTINIB" @default.
- NCIT_C133691 hasExactSynonym "Almonertinib" @default.
- NCIT_C133691 hasExactSynonym "Aumolertinib" @default.
- NCIT_C133691 hasExactSynonym "EGFR Tyrosine Kinase Inhibitor HS-10296" @default.
- NCIT_C133691 hasExactSynonym "EQ143" @default.
- NCIT_C133691 hasExactSynonym "HS-10296" @default.
- NCIT_C133691 inSubset NCIT_C116977 @default.
- NCIT_C133691 inSubset NCIT_C116978 @default.
- NCIT_C133691 inSubset NCIT_C128784 @default.
- NCIT_C133691 inSubset NCIT_C157711 @default.
- NCIT_C133691 inSubset NCIT_C157712 @default.
- NCIT_C133691 inSubset NCIT_C176424 @default.
- NCIT_C133691 inSubset NCIT_C177537 @default.
- NCIT_C133691 inSubset NCIT_C63923 @default.
- NCIT_C133691 type Class @default.
- NCIT_C133691 isDefinedBy ncit.owl @default.
- NCIT_C133691 label "Aumolertinib" @default.
- NCIT_C133691 subClassOf NCIT_C129824 @default.
- NCIT_C133691 subClassOf NCIT_C129825 @default.
- NCIT_C133691 subClassOf NCIT_C133691 @default.
- NCIT_C133691 subClassOf NCIT_C1404 @default.
- NCIT_C133691 subClassOf NCIT_C163758 @default.
- NCIT_C133691 subClassOf NCIT_C163952 @default.
- NCIT_C133691 subClassOf NCIT_C1908 @default.
- NCIT_C133691 subClassOf NCIT_C1909 @default.
- NCIT_C133691 subClassOf NCIT_C1967 @default.
- NCIT_C133691 subClassOf NCIT_C2167 @default.
- NCIT_C133691 subClassOf NCIT_C2189 @default.
- NCIT_C133691 subClassOf NCIT_C274 @default.
- NCIT_C133691 subClassOf NCIT_C471 @default.