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- NCIT_C133717 IAO_0000115 "A poly (ADP-ribose) polymerase type 1 (PARP1) fluorescence imaging agent based on the PARP1 inhibitor olaparib, in which the cyclopropane group of olaparib is replaced by the green fluorescent dye boron-dipyrromethene (BODIPY) fluorophore (FL), with potential fluorescent imaging activity. Upon administration of the fluorescent PARP1 inhibitor PARPi-FL, the olaparib binding moiety specifically targets and binds to PARP1, which is often overexpressed on cancer cells. Upon fluorescent imaging, the PARP1-expressing cancer cells can be visualized. PARP1, the nuclear enzyme that catalyzes post-translational ADP-ribosylation of nuclear proteins, is activated by single-strand (SS) DNA breaks and overexpressed in certain tumor cells; it plays a key role in DNA repair, tumor cell resistance and survival." @default.
- NCIT_C133717 NCIT_A7 NCIT_C48215 @default.
- NCIT_C133717 NCIT_NHC0 "C133717" @default.
- NCIT_C133717 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C133717 NCIT_P107 "Boron-dipyrromethene-modified Olaparib Fluorescent Imaging Agent" @default.
- NCIT_C133717 NCIT_P108 "Boron-dipyrromethene-modified Olaparib Fluorescent Imaging Agent" @default.
- NCIT_C133717 NCIT_P208 "CL519696" @default.
- NCIT_C133717 NCIT_P210 "1380359-84-1" @default.
- NCIT_C133717 NCIT_P319 "ZMX54372EH" @default.
- NCIT_C133717 NCIT_P322 "CTRP" @default.
- NCIT_C133717 NCIT_P322 "FDA" @default.
- NCIT_C133717 NCIT_P329 "788166" @default.
- NCIT_C133717 NCIT_P330 "788166" @default.
- NCIT_C133717 NCIT_P399 "788166" @default.
- NCIT_C133717 normalizedInformationContent "100" @default.
- NCIT_C133717 referenceCount "1" @default.
- NCIT_C133717 hasExactSynonym "ABY-029" @default.
- NCIT_C133717 hasExactSynonym "AZD2281-BODIPY FL" @default.
- NCIT_C133717 hasExactSynonym "BODIPY-modified Olaparib Fluorescent Imaging Agent" @default.
- NCIT_C133717 hasExactSynonym "Boron, (4-((3-((4-(3-(5-((3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)methyl)-1H-pyrrol-2-yl-kappaN)-1-oxopropyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-1(2H)-phthalazinonato)difluoro-, (T-4)-" @default.
- NCIT_C133717 hasExactSynonym "Boron-dipyrromethene-modified Olaparib Fluorescent Imaging Agent" @default.
- NCIT_C133717 hasExactSynonym "Fluorescent PARP1 Inhibitor PARPi-FL" @default.
- NCIT_C133717 hasExactSynonym "Fluorescent PARPi Binding Imaging Agent PARPi-FL" @default.
- NCIT_C133717 hasExactSynonym "OLAPARIB-BODIPY FL" @default.
- NCIT_C133717 hasExactSynonym "Olaparib-BODIPY FL" @default.
- NCIT_C133717 hasExactSynonym "PARPi-FL" @default.
- NCIT_C133717 inSubset NCIT_C116977 @default.
- NCIT_C133717 inSubset NCIT_C116978 @default.
- NCIT_C133717 inSubset NCIT_C176424 @default.
- NCIT_C133717 inSubset NCIT_C63923 @default.
- NCIT_C133717 type Class @default.
- NCIT_C133717 isDefinedBy ncit.owl @default.
- NCIT_C133717 label "Boron-dipyrromethene-modified Olaparib Fluorescent Imaging Agent" @default.
- NCIT_C133717 subClassOf NCIT_C133717 @default.
- NCIT_C133717 subClassOf NCIT_C1908 @default.
- NCIT_C133717 subClassOf NCIT_C1966 @default.
- NCIT_C133717 subClassOf NCIT_C45678 @default.
- NCIT_C133717 subClassOf NCIT_C802 @default.