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- NCIT_C133718 IAO_0000115 "Genetically modified CD3-positive-enriched autologous T-lymphocytes transduced with a replication incompetent gamma retroviral vector expressing a chimeric T-cell antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (CAR19-28z), with potential antineoplastic activities. Upon intravenous administration, vadacabtagene leraleucel,is directed to CD19-expressing tumor cells, and, upon binding to the T-cells, induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone." @default.
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- NCIT_C133718 NCIT_NHC0 "C133718" @default.
- NCIT_C133718 NCIT_P106 "Cell" @default.
- NCIT_C133718 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133718 NCIT_P108 "Vadacabtagene Leraleucel" @default.
- NCIT_C133718 NCIT_P208 "CL520442" @default.
- NCIT_C133718 NCIT_P319 "A4O2H9W17Y" @default.
- NCIT_C133718 NCIT_P322 "FDA" @default.
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- NCIT_C133718 NCIT_P329 "788214" @default.
- NCIT_C133718 NCIT_P330 "788214" @default.
- NCIT_C133718 NCIT_P375 "Vadacabtagene Leraleucel" @default.
- NCIT_C133718 NCIT_P399 "788214" @default.
- NCIT_C133718 NCIT_P98 "Clinical trial NCT02973191 has been terminated due to incidence of neurotoxicity and related deaths. 04/18/2017" @default.
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- NCIT_C133718 NCIT_R72 NCIT_C32725 @default.
- NCIT_C133718 NCIT_R72 NCIT_C33061 @default.
- NCIT_C133718 NCIT_R72 NCIT_C38434 @default.
- NCIT_C133718 NCIT_R72 NCIT_C38439 @default.
- NCIT_C133718 NCIT_R72 NCIT_C39567 @default.
- NCIT_C133718 NCIT_R72 NCIT_C39568 @default.
- NCIT_C133718 normalizedInformationContent "100" @default.
- NCIT_C133718 referenceCount "1" @default.
- NCIT_C133718 hasExactSynonym "Anti-CD19/CD28/zeta Modified CAR CD3+ T Lymphocytes JCAR015" @default.
- NCIT_C133718 hasExactSynonym "JCAR 015" @default.
- NCIT_C133718 hasExactSynonym "JCAR 15" @default.
- NCIT_C133718 hasExactSynonym "JCAR015" @default.
- NCIT_C133718 hasExactSynonym "VADACABTAGENE LERALEUCEL" @default.
- NCIT_C133718 hasExactSynonym "Vadacabtagene Leraleucel" @default.
- NCIT_C133718 inSubset NCIT_C128784 @default.
- NCIT_C133718 inSubset NCIT_C157711 @default.
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- NCIT_C133718 type Class @default.
- NCIT_C133718 isDefinedBy ncit.owl @default.
- NCIT_C133718 label "Vadacabtagene Leraleucel" @default.
- NCIT_C133718 subClassOf NCIT_C129820 @default.
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