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- NCIT_C133719 IAO_0000115 "The mesylate salt form of alflutinib, an orally available selective inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, alflutinib specifically binds to and inhibits the tyrosine kinase activity of EGFR T790M, a secondarily acquired resistance mutation. This prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Compared to some other EGFR inhibitors, alflutinib may have therapeutic benefits in tumors with T790M-mediated drug resistance." @default.
- NCIT_C133719 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133719 NCIT_A6 NCIT_C180535 @default.
- NCIT_C133719 NCIT_A7 NCIT_C98503 @default.
- NCIT_C133719 NCIT_NHC0 "C133719" @default.
- NCIT_C133719 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133719 NCIT_P108 "Alflutinib Mesylate" @default.
- NCIT_C133719 NCIT_P208 "CL520357" @default.
- NCIT_C133719 NCIT_P210 "2130958-55-1" @default.
- NCIT_C133719 NCIT_P319 "Q09ZKD19V0" @default.
- NCIT_C133719 NCIT_P322 "FDA" @default.
- NCIT_C133719 NCIT_P322 "GDC" @default.
- NCIT_C133719 NCIT_P329 "788215" @default.
- NCIT_C133719 NCIT_P330 "788215" @default.
- NCIT_C133719 NCIT_P375 "Alflutinib Mesylate" @default.
- NCIT_C133719 NCIT_P399 "788215" @default.
- NCIT_C133719 normalizedInformationContent "100" @default.
- NCIT_C133719 referenceCount "1" @default.
- NCIT_C133719 hasExactSynonym "ASK120067" @default.
- NCIT_C133719 hasExactSynonym "AST 2818 Mesylate" @default.
- NCIT_C133719 hasExactSynonym "AST2818 Mesylate" @default.
- NCIT_C133719 hasExactSynonym "Alflutinib Mesylate" @default.
- NCIT_C133719 hasExactSynonym "FURMONERTINIB MESILATE" @default.
- NCIT_C133719 hasExactSynonym "Furmonertinib Mesylate" @default.
- NCIT_C133719 hasExactSynonym "Ivesa" @default.
- NCIT_C133719 inSubset NCIT_C128784 @default.
- NCIT_C133719 inSubset NCIT_C157711 @default.
- NCIT_C133719 inSubset NCIT_C157712 @default.
- NCIT_C133719 inSubset NCIT_C176424 @default.
- NCIT_C133719 inSubset NCIT_C177537 @default.
- NCIT_C133719 inSubset NCIT_C63923 @default.
- NCIT_C133719 type Class @default.
- NCIT_C133719 isDefinedBy ncit.owl @default.
- NCIT_C133719 label "Alflutinib Mesylate" @default.
- NCIT_C133719 subClassOf NCIT_C129824 @default.
- NCIT_C133719 subClassOf NCIT_C129825 @default.
- NCIT_C133719 subClassOf NCIT_C133719 @default.
- NCIT_C133719 subClassOf NCIT_C1404 @default.
- NCIT_C133719 subClassOf NCIT_C163758 @default.
- NCIT_C133719 subClassOf NCIT_C163952 @default.
- NCIT_C133719 subClassOf NCIT_C1908 @default.
- NCIT_C133719 subClassOf NCIT_C1909 @default.
- NCIT_C133719 subClassOf NCIT_C1967 @default.
- NCIT_C133719 subClassOf NCIT_C2167 @default.
- NCIT_C133719 subClassOf NCIT_C2189 @default.
- NCIT_C133719 subClassOf NCIT_C274 @default.
- NCIT_C133719 subClassOf NCIT_C471 @default.