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- NCIT_C133720 IAO_0000115 "An orally bioavailable capsule formulation of the inorganic toxic compound arsenic trioxide (As2O3), with potential antineoplastic activity. Although the mechanism of action (MoA) of As2O3 is not well understood, upon oral administration of ORH 2014, As2O3 appears to bind to DNA, prevent DNA synthesis, and cause DNA fragmentation, which leads to an induction of apoptosis in proliferating cells, including tumor cells. In addition, As2O3 causes damage to and induces degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein, and inhibits the activity of the enzyme thioredoxin reductase." @default.
- NCIT_C133720 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133720 NCIT_NHC0 "C133720" @default.
- NCIT_C133720 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133720 NCIT_P107 "Arsenic Trioxide Capsule Formulation ORH 2014" @default.
- NCIT_C133720 NCIT_P108 "Arsenic Trioxide Capsule Formulation ORH 2014" @default.
- NCIT_C133720 NCIT_P208 "CL520496" @default.
- NCIT_C133720 NCIT_P322 "CTRP" @default.
- NCIT_C133720 NCIT_P322 "GDC" @default.
- NCIT_C133720 NCIT_P329 "788312" @default.
- NCIT_C133720 NCIT_P330 "788312" @default.
- NCIT_C133720 NCIT_P375 "Arsenic Trioxide Capsule Formulation ORH 2014" @default.
- NCIT_C133720 NCIT_P399 "788312" @default.
- NCIT_C133720 normalizedInformationContent "100" @default.
- NCIT_C133720 referenceCount "1" @default.
- NCIT_C133720 hasExactSynonym "Arsenic Trioxide Capsule Formulation ORH 2014" @default.
- NCIT_C133720 hasExactSynonym "Arsenic Trioxide Formulation ORH 2014" @default.
- NCIT_C133720 hasExactSynonym "As2O3 Formulation ORH 2014" @default.
- NCIT_C133720 hasExactSynonym "ORH 2014" @default.
- NCIT_C133720 hasExactSynonym "Oral Arsenic Trioxide Formulation" @default.
- NCIT_C133720 inSubset NCIT_C116977 @default.
- NCIT_C133720 inSubset NCIT_C116978 @default.
- NCIT_C133720 inSubset NCIT_C128784 @default.
- NCIT_C133720 inSubset NCIT_C157711 @default.
- NCIT_C133720 inSubset NCIT_C157712 @default.
- NCIT_C133720 inSubset NCIT_C176424 @default.
- NCIT_C133720 inSubset NCIT_C177537 @default.
- NCIT_C133720 type Class @default.
- NCIT_C133720 isDefinedBy ncit.owl @default.
- NCIT_C133720 label "Arsenic Trioxide Capsule Formulation ORH 2014" @default.
- NCIT_C133720 subClassOf NCIT_C133720 @default.
- NCIT_C133720 subClassOf NCIT_C1908 @default.
- NCIT_C133720 subClassOf NCIT_C1909 @default.
- NCIT_C133720 subClassOf NCIT_C1934 @default.
- NCIT_C133720 subClassOf NCIT_C2122 @default.
- NCIT_C133720 subClassOf NCIT_C274 @default.