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- NCIT_C133745 IAO_0000115 "A mutagenic and carcinogenic cyclic 1,N2-propanodeoxy (Pd) DNA adduct derived from the reaction of deoxyguanosine (dG) in DNA with the environmentally widely available or endogenously produced mutagenic and carcinogenic unsaturated aldehyde acrolein (Acr) that can potentially be used as a biomarker for exposure to Acr, the formation of certain forms of cancer and the presence of oxidative stress. The formation of gamma-hydroxy-1,N(2)-propanodeoxyguanosine (g-OH-PdG) damages DNA and stimulates the formation of tumors. Also, as Acr is formed due to oxidation of certain polyunsaturated fatty acids (PUFAs), mostly omega-3-PUFA, the lipid peroxidation-derived DNA adduct g-OH-PdG can potentially be used as a biomarker to assess the presence of oxidized PUFAs, the level of oxidative stress and the extent of oxidative DNA damage." @default.
- NCIT_C133745 NCIT_NHC0 "C133745" @default.
- NCIT_C133745 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C133745 NCIT_P107 "Gamma-hydroxy-1,N(2)-propanodeoxyguanosine" @default.
- NCIT_C133745 NCIT_P108 "Gamma-hydroxy-1,N(2)-propanodeoxyguanosine" @default.
- NCIT_C133745 NCIT_P208 "CL521680" @default.
- NCIT_C133745 NCIT_P322 "CTRP" @default.
- NCIT_C133745 normalizedInformationContent "100" @default.
- NCIT_C133745 referenceCount "1" @default.
- NCIT_C133745 hasExactSynonym "3-(2'-Deoxy-beta-d-erythro-pentofuranosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-a] Purin-10(3H)-one" @default.
- NCIT_C133745 hasExactSynonym "Acr-dG3" @default.
- NCIT_C133745 hasExactSynonym "Acrolein-dG3" @default.
- NCIT_C133745 hasExactSynonym "Gamma-hydroxy-1,N(2)-propanodeoxyguanosine" @default.
- NCIT_C133745 hasExactSynonym "g-OH-PdG" @default.
- NCIT_C133745 hasExactSynonym "g-OHPdG" @default.
- NCIT_C133745 hasExactSynonym "gamma-OH-PdG" @default.
- NCIT_C133745 hasExactSynonym "gamma-OHPdG" @default.
- NCIT_C133745 inSubset NCIT_C116977 @default.
- NCIT_C133745 inSubset NCIT_C142799 @default.
- NCIT_C133745 type Class @default.
- NCIT_C133745 isDefinedBy ncit.owl @default.
- NCIT_C133745 label "Gamma-hydroxy-1,N(2)-propanodeoxyguanosine" @default.
- NCIT_C133745 subClassOf NCIT_C133745 @default.
- NCIT_C133745 subClassOf NCIT_C1908 @default.
- NCIT_C133745 subClassOf NCIT_C1913 @default.
- NCIT_C133745 subClassOf NCIT_C707 @default.
- NCIT_C133745 subClassOf NCIT_C708 @default.
- NCIT_C133745 subClassOf NCIT_C718 @default.