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- NCIT_C133821 IAO_0000115 "An orally available inhibitor of multiple kinases, including the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, the proto-oncogene SRC, and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon oral administration, repotrectinib binds to and inhibits wild-type, point mutants and fusion proteins of ALK, ROS1, NTRK1-3, SRC, FAK and, to a lesser extent, other kinases. Inhibition of these kinases leads to the disruption of downstream signaling pathways and the inhibition of cell growth of tumors in which these kinases are overexpressed, rearranged or mutated." @default.
- NCIT_C133821 NCIT_A32 NCIT_C1909 @default.
- NCIT_C133821 NCIT_A7 NCIT_C17389 @default.
- NCIT_C133821 NCIT_A7 NCIT_C17572 @default.
- NCIT_C133821 NCIT_A7 NCIT_C17691 @default.
- NCIT_C133821 NCIT_A7 NCIT_C27032 @default.
- NCIT_C133821 NCIT_A7 NCIT_C28558 @default.
- NCIT_C133821 NCIT_A7 NCIT_C33983 @default.
- NCIT_C133821 NCIT_A7 NCIT_C33984 @default.
- NCIT_C133821 NCIT_NHC0 "C133821" @default.
- NCIT_C133821 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C133821 NCIT_P107 "Repotrectinib" @default.
- NCIT_C133821 NCIT_P108 "Repotrectinib" @default.
- NCIT_C133821 NCIT_P208 "CL521742" @default.
- NCIT_C133821 NCIT_P210 "1802220-02-5" @default.
- NCIT_C133821 NCIT_P319 "08O3FQ4UNP" @default.
- NCIT_C133821 NCIT_P322 "CTRP" @default.
- NCIT_C133821 NCIT_P322 "FDA" @default.
- NCIT_C133821 NCIT_P322 "GDC" @default.
- NCIT_C133821 NCIT_P329 "788549" @default.
- NCIT_C133821 NCIT_P330 "788549" @default.
- NCIT_C133821 NCIT_P375 "Repotrectinib" @default.
- NCIT_C133821 NCIT_P399 "788549" @default.
- NCIT_C133821 normalizedInformationContent "100" @default.
- NCIT_C133821 referenceCount "1" @default.
- NCIT_C133821 hasExactSynonym "ALK/ROS1/NTRK/SRC/FAK Multikinase Inhibitor TPX-0005" @default.
- NCIT_C133821 hasExactSynonym "Multi-kinase Inhibitor TPX-0005" @default.
- NCIT_C133821 hasExactSynonym "Multikinase Inhibitor TPX-0005" @default.
- NCIT_C133821 hasExactSynonym "REPOTRECTINIB" @default.
- NCIT_C133821 hasExactSynonym "Repotrectinib" @default.
- NCIT_C133821 hasExactSynonym "TPX-0005" @default.
- NCIT_C133821 inSubset NCIT_C116977 @default.
- NCIT_C133821 inSubset NCIT_C116978 @default.
- NCIT_C133821 inSubset NCIT_C128784 @default.
- NCIT_C133821 inSubset NCIT_C157711 @default.
- NCIT_C133821 inSubset NCIT_C157712 @default.
- NCIT_C133821 inSubset NCIT_C176424 @default.
- NCIT_C133821 inSubset NCIT_C177537 @default.
- NCIT_C133821 inSubset NCIT_C63923 @default.
- NCIT_C133821 type Class @default.
- NCIT_C133821 isDefinedBy ncit.owl @default.
- NCIT_C133821 label "Repotrectinib" @default.
- NCIT_C133821 subClassOf NCIT_C133821 @default.
- NCIT_C133821 subClassOf NCIT_C1404 @default.
- NCIT_C133821 subClassOf NCIT_C1908 @default.
- NCIT_C133821 subClassOf NCIT_C1909 @default.
- NCIT_C133821 subClassOf NCIT_C1967 @default.
- NCIT_C133821 subClassOf NCIT_C471 @default.