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- NCIT_C1340 IAO_0000115 "A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations." @default.
- NCIT_C1340 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1340 NCIT_NHC0 "C1340" @default.
- NCIT_C1340 NCIT_P106 "Antibiotic" @default.
- NCIT_C1340 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1340 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1340 NCIT_P107 "Valrubicin" @default.
- NCIT_C1340 NCIT_P108 "Valrubicin" @default.
- NCIT_C1340 NCIT_P175 "246131" @default.
- NCIT_C1340 NCIT_P207 "C0068314" @default.
- NCIT_C1340 NCIT_P210 "56124-62-0" @default.
- NCIT_C1340 NCIT_P319 "2C6NUM6878" @default.
- NCIT_C1340 NCIT_P322 "CTRP" @default.
- NCIT_C1340 NCIT_P322 "FDA" @default.
- NCIT_C1340 NCIT_P322 "GDC" @default.
- NCIT_C1340 NCIT_P325 "A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic." @default.
- NCIT_C1340 NCIT_P329 "39135" @default.
- NCIT_C1340 NCIT_P330 "39135" @default.
- NCIT_C1340 NCIT_P350 "C34H36F3NO13" @default.
- NCIT_C1340 NCIT_P366 "Valrubicin" @default.
- NCIT_C1340 NCIT_P375 "Valrubicin" @default.
- NCIT_C1340 NCIT_P399 "39135" @default.
- NCIT_C1340 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1340 referenceCount "2" @default.
- NCIT_C1340 hasExactSynonym "AD 32" @default.
- NCIT_C1340 hasExactSynonym "AD-32" @default.
- NCIT_C1340 hasExactSynonym "N-Trifluoroacetyladriamycin-14-valerate" @default.
- NCIT_C1340 hasExactSynonym "VALRUBICIN" @default.
- NCIT_C1340 hasExactSynonym "Valrubicin" @default.
- NCIT_C1340 hasExactSynonym "Valstar" @default.
- NCIT_C1340 hasExactSynonym "Valtaxin" @default.
- NCIT_C1340 hasExactSynonym "valrubicin" @default.
- NCIT_C1340 inSubset NCIT_C116977 @default.
- NCIT_C1340 inSubset NCIT_C116978 @default.
- NCIT_C1340 inSubset NCIT_C128784 @default.
- NCIT_C1340 inSubset NCIT_C157711 @default.
- NCIT_C1340 inSubset NCIT_C157712 @default.
- NCIT_C1340 inSubset NCIT_C176424 @default.
- NCIT_C1340 inSubset NCIT_C177537 @default.
- NCIT_C1340 inSubset NCIT_C63923 @default.
- NCIT_C1340 type Class @default.
- NCIT_C1340 isDefinedBy ncit.owl @default.
- NCIT_C1340 label "Valrubicin" @default.
- NCIT_C1340 subClassOf NCIT_C129824 @default.
- NCIT_C1340 subClassOf NCIT_C129825 @default.
- NCIT_C1340 subClassOf NCIT_C1340 @default.
- NCIT_C1340 subClassOf NCIT_C1594 @default.
- NCIT_C1340 subClassOf NCIT_C1748 @default.
- NCIT_C1340 subClassOf NCIT_C186664 @default.
- NCIT_C1340 subClassOf NCIT_C1908 @default.
- NCIT_C1340 subClassOf NCIT_C1909 @default.
- NCIT_C1340 subClassOf NCIT_C1968 @default.
- NCIT_C1340 subClassOf NCIT_C2115 @default.
- NCIT_C1340 subClassOf NCIT_C2161 @default.
- NCIT_C1340 subClassOf NCIT_C2189 @default.
- NCIT_C1340 subClassOf NCIT_C259 @default.
- NCIT_C1340 subClassOf NCIT_C274 @default.
- NCIT_C1340 subClassOf NCIT_C2842 @default.
- NCIT_C1340 subClassOf NCIT_C471 @default.