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- NCIT_C134502 IAO_0000115 "An assay that indirectly quantitates the expression of the antiapoptotic protein, induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1; EAT), in a biological sample. Mitochondria or whole cells are isolated from a patient sample and stained with JC-1. In healthy cells with high mitochondrial membrane potential, JC-1 forms aggregates that emit red fluorescence, while in apoptotic cells with low mitochondrial membrane potential, JC-1 remains a monomer, which emits green fluorescence. The isolate is then exposed to a peptide comprised of the BH3 domain of phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1; NOXA), which specifically binds to and inhibits the antiapoptotic activity of MCL1. Then the mitochondrial outer membrane permeability (MOMP) is assessed by determining the ratio of red and green JC-1 fluorescence." @default.
- NCIT_C134502 NCIT_A13 NCIT_C20412 @default.
- NCIT_C134502 NCIT_NHC0 "C134502" @default.
- NCIT_C134502 NCIT_P106 "Laboratory Procedure" @default.
- NCIT_C134502 NCIT_P107 "NOXA BH3 Priming" @default.
- NCIT_C134502 NCIT_P108 "NOXA BH3 Priming" @default.
- NCIT_C134502 NCIT_P171 "22230093" @default.
- NCIT_C134502 NCIT_P208 "CL522085" @default.
- NCIT_C134502 NCIT_P322 "CTRP" @default.
- NCIT_C134502 normalizedInformationContent "100" @default.
- NCIT_C134502 referenceCount "1" @default.
- NCIT_C134502 hasExactSynonym "NOXA BH3 Priming" @default.
- NCIT_C134502 hasExactSynonym "PMAIP1 BH3 Priming" @default.
- NCIT_C134502 inSubset NCIT_C116977 @default.
- NCIT_C134502 inSubset NCIT_C142799 @default.
- NCIT_C134502 inSubset NCIT_C142800 @default.
- NCIT_C134502 type Class @default.
- NCIT_C134502 isDefinedBy ncit.owl @default.
- NCIT_C134502 label "NOXA BH3 Priming" @default.
- NCIT_C134502 subClassOf NCIT_C134502 @default.
- NCIT_C134502 subClassOf NCIT_C16203 @default.
- NCIT_C134502 subClassOf NCIT_C25218 @default.
- NCIT_C134502 subClassOf NCIT_C25294 @default.
- NCIT_C134502 subClassOf NCIT_C43431 @default.
- NCIT_C134502 subClassOf NCIT_C49237 @default.
- NCIT_C134502 subClassOf NCIT_C64430 @default.
- NCIT_C134502 subClassOf NCIT_C74944 @default.