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- NCIT_C134697 IAO_0000115 "A probody drug conjugate (PDC) composed of a recombinant antibody targeting the tumor-associated antigen (TAA) CD166, which is masked by a cleavable masking peptide, and conjugated to the cytotoxic agent maytansinoid DM4, with potential antineoplastic activity. Upon administration of praluzatamab ravtansine and migration to the tumor microenvironment (TME), the cleavable masking peptide, which prevent anti-CD166 antibody binding to the CD166 expressed on both normal cells and tumor cells, is proteolytically cleaved by tumor-associated proteases that are specifically present in the TME. This enables the anti-CD166 antibody moiety of CX-2009 to selectively bind to, be internalized by, and deliver DM4 into CD166-expressing tumor cells. Following internalization, DM4 is released, binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of CD166-expressing tumor cells. The masking peptide prevents binding of the anti-CD166 antibody to CD166 in normal tissues, thereby minimizing toxicities." @default.
- NCIT_C134697 NCIT_A32 NCIT_C1909 @default.
- NCIT_C134697 NCIT_A7 NCIT_C17920 @default.
- NCIT_C134697 NCIT_NHC0 "C134697" @default.
- NCIT_C134697 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C134697 NCIT_P108 "Praluzatamab Ravtansine" @default.
- NCIT_C134697 NCIT_P208 "CL522231" @default.
- NCIT_C134697 NCIT_P210 "2145115-85-9" @default.
- NCIT_C134697 NCIT_P319 "RD2I59M9FC" @default.
- NCIT_C134697 NCIT_P322 "FDA" @default.
- NCIT_C134697 NCIT_P322 "GDC" @default.
- NCIT_C134697 NCIT_P329 "789027" @default.
- NCIT_C134697 NCIT_P330 "789027" @default.
- NCIT_C134697 NCIT_P375 "Anti-CD166 Probody-drug Conjugate CX-2009" @default.
- NCIT_C134697 NCIT_P375 "Praluzatamab Ravtansine" @default.
- NCIT_C134697 NCIT_P399 "789027" @default.
- NCIT_C134697 normalizedInformationContent "100" @default.
- NCIT_C134697 referenceCount "1" @default.
- NCIT_C134697 hasExactSynonym "ADC CX-2009" @default.
- NCIT_C134697 hasExactSynonym "Anti-CD166-DM4 CX-2009" @default.
- NCIT_C134697 hasExactSynonym "CX-2009" @default.
- NCIT_C134697 hasExactSynonym "PDC CX-2009" @default.
- NCIT_C134697 hasExactSynonym "PRALUZATAMAB RAVTANSINE" @default.
- NCIT_C134697 hasExactSynonym "Praluzatamab Ravtansine" @default.
- NCIT_C134697 inSubset NCIT_C128784 @default.
- NCIT_C134697 inSubset NCIT_C157711 @default.
- NCIT_C134697 inSubset NCIT_C157712 @default.
- NCIT_C134697 inSubset NCIT_C176424 @default.
- NCIT_C134697 inSubset NCIT_C177537 @default.
- NCIT_C134697 inSubset NCIT_C63923 @default.
- NCIT_C134697 type Class @default.
- NCIT_C134697 isDefinedBy ncit.owl @default.
- NCIT_C134697 label "Praluzatamab Ravtansine" @default.
- NCIT_C134697 subClassOf NCIT_C129821 @default.
- NCIT_C134697 subClassOf NCIT_C129823 @default.
- NCIT_C134697 subClassOf NCIT_C134697 @default.
- NCIT_C134697 subClassOf NCIT_C1512 @default.
- NCIT_C134697 subClassOf NCIT_C1908 @default.
- NCIT_C134697 subClassOf NCIT_C1909 @default.
- NCIT_C134697 subClassOf NCIT_C274 @default.
- NCIT_C134697 subClassOf NCIT_C307 @default.
- NCIT_C134697 subClassOf NCIT_C308 @default.