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- NCIT_C134967 IAO_0000115 "A selective inhibitor of mutated forms of B-RAF kinase at amino acid position 600 (BRAFV600), including BRAFV600E, the alpha, delta and, to a lesser extent, beta isoforms of phosphatidylinositide 3-kinase (PI3K), including mutated forms of PI3KCA, which encodes the p110-alpha catalytic subunit of the class I PI3K, and the phosphatase and tensin homologs (PTEN) with loss-of-function mutation, with potential antineoplastic activity. Upon administration of ASN003, this agent selectively targets, binds to and inhibits the activity of BRAFV600 mutants as well as mutated isoforms of PI3K. This inhibits signaling through B-RAF- and PI3K/mechanistic target of rapamycin (mTOR)-mediated pathways and inhibits cellular proliferation in tumor cells with BRAFV600 mutations, those expressing PI3K and/or those driven by PTEN. Dysregulation of the B-RAF- and PI3K-mediated pathways is frequently seen in a variety of tumors and results in increased tumor cell growth and survival. Dual targeting of both pathways may increase efficacy and anti-tumor potential compared to the targeting of just one pathway by a selective B-RAF inhibitor or selective PI3K pathway inhibitor alone." @default.
- NCIT_C134967 NCIT_A32 NCIT_C1909 @default.
- NCIT_C134967 NCIT_A7 NCIT_C113631 @default.
- NCIT_C134967 NCIT_A7 NCIT_C30168 @default.
- NCIT_C134967 NCIT_A7 NCIT_C30170 @default.
- NCIT_C134967 NCIT_NHC0 "C134967" @default.
- NCIT_C134967 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C134967 NCIT_P107 "BRAFV600/PI3K Inhibitor ASN003" @default.
- NCIT_C134967 NCIT_P108 "BRAFV600/PI3K Inhibitor ASN003" @default.
- NCIT_C134967 NCIT_P208 "CL522477" @default.
- NCIT_C134967 NCIT_P322 "CTRP" @default.
- NCIT_C134967 NCIT_P322 "GDC" @default.
- NCIT_C134967 NCIT_P329 "789080" @default.
- NCIT_C134967 NCIT_P330 "789080" @default.
- NCIT_C134967 NCIT_P375 "BRAFV600/PI3K Inhibitor ASN003" @default.
- NCIT_C134967 NCIT_P399 "789080" @default.
- NCIT_C134967 normalizedInformationContent "100" @default.
- NCIT_C134967 referenceCount "1" @default.
- NCIT_C134967 hasExactSynonym "ASN 003" @default.
- NCIT_C134967 hasExactSynonym "ASN-003" @default.
- NCIT_C134967 hasExactSynonym "ASN003" @default.
- NCIT_C134967 hasExactSynonym "BRAFV600/PI3K Inhibitor ASN003" @default.
- NCIT_C134967 inSubset NCIT_C116977 @default.
- NCIT_C134967 inSubset NCIT_C116978 @default.
- NCIT_C134967 inSubset NCIT_C128784 @default.
- NCIT_C134967 inSubset NCIT_C157711 @default.
- NCIT_C134967 inSubset NCIT_C157712 @default.
- NCIT_C134967 inSubset NCIT_C176424 @default.
- NCIT_C134967 inSubset NCIT_C177537 @default.
- NCIT_C134967 type Class @default.
- NCIT_C134967 isDefinedBy ncit.owl @default.
- NCIT_C134967 label "BRAFV600/PI3K Inhibitor ASN003" @default.
- NCIT_C134967 subClassOf NCIT_C129824 @default.
- NCIT_C134967 subClassOf NCIT_C129825 @default.
- NCIT_C134967 subClassOf NCIT_C134967 @default.
- NCIT_C134967 subClassOf NCIT_C1404 @default.
- NCIT_C134967 subClassOf NCIT_C155322 @default.
- NCIT_C134967 subClassOf NCIT_C163758 @default.
- NCIT_C134967 subClassOf NCIT_C1742 @default.
- NCIT_C134967 subClassOf NCIT_C1908 @default.
- NCIT_C134967 subClassOf NCIT_C1909 @default.
- NCIT_C134967 subClassOf NCIT_C2152 @default.
- NCIT_C134967 subClassOf NCIT_C2189 @default.
- NCIT_C134967 subClassOf NCIT_C2336 @default.
- NCIT_C134967 subClassOf NCIT_C274 @default.
- NCIT_C134967 subClassOf NCIT_C471 @default.
- NCIT_C134967 subClassOf NCIT_C61074 @default.