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- NCIT_C134987 IAO_0000115 "An orally bioavailable selective inhibitor of wild-type, mutant and fusion products involving the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, selpercatinib selectively binds to and targets wild-type RET as well as various RET mutants and RET-containing fusion products. This results in an inhibition of cell growth of tumors cells that exhibit increased RET activity. In addition, selpercatinib targets, binds to and inhibits vascular endothelial growth factor receptor 1 (VEGFR1) and 3 (VEGFR3), and fibroblast growth factor receptor 1 (FGFR1), 2 (FGFR2), and 3 (FGFR3). RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers." @default.
- NCIT_C134987 NCIT_A32 NCIT_C1909 @default.
- NCIT_C134987 NCIT_A7 NCIT_C18539 @default.
- NCIT_C134987 NCIT_NHC0 "C134987" @default.
- NCIT_C134987 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C134987 NCIT_P107 "Selpercatinib" @default.
- NCIT_C134987 NCIT_P108 "Selpercatinib" @default.
- NCIT_C134987 NCIT_P208 "CL522497" @default.
- NCIT_C134987 NCIT_P210 "2152628-33-4" @default.
- NCIT_C134987 NCIT_P302 "Adult patients with metastatic RET fusion-positive non-small cell lung cancer (NSCLC); • Adult and pediatric patients ≥12 years of age with advanced or metastatic RET-mutant medullary thyroid cancer (MTC) who require systemic therapy; • Adult and pediatric patients ≥12 years of age with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate)." @default.
- NCIT_C134987 NCIT_P319 "CEGM9YBNGD" @default.
- NCIT_C134987 NCIT_P322 "CTRP" @default.
- NCIT_C134987 NCIT_P322 "FDA" @default.
- NCIT_C134987 NCIT_P322 "GDC" @default.
- NCIT_C134987 NCIT_P329 "789226" @default.
- NCIT_C134987 NCIT_P330 "789226" @default.
- NCIT_C134987 NCIT_P375 "Selpercatinib" @default.
- NCIT_C134987 NCIT_P399 "789226" @default.
- NCIT_C134987 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C134987 referenceCount "2" @default.
- NCIT_C134987 hasExactSynonym "6-(2-Hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo(3.1.1)heptan-3-yl)pyridin-3-yl)pyrazolo(1,5-a)pyridine-3-carbonitrile" @default.
- NCIT_C134987 hasExactSynonym "LOXO-292" @default.
- NCIT_C134987 hasExactSynonym "RET Inhibitor LOXO-292" @default.
- NCIT_C134987 hasExactSynonym "RET Kinase Inhibitor LOXO-292" @default.
- NCIT_C134987 hasExactSynonym "Retevmo" @default.
- NCIT_C134987 hasExactSynonym "Retsevmo" @default.
- NCIT_C134987 hasExactSynonym "SELPERCATINIB" @default.
- NCIT_C134987 hasExactSynonym "Selpercatinib" @default.
- NCIT_C134987 hasExactSynonym "WHO 10967" @default.
- NCIT_C134987 inSubset NCIT_C116977 @default.
- NCIT_C134987 inSubset NCIT_C116978 @default.
- NCIT_C134987 inSubset NCIT_C128784 @default.
- NCIT_C134987 inSubset NCIT_C157711 @default.
- NCIT_C134987 inSubset NCIT_C157712 @default.
- NCIT_C134987 inSubset NCIT_C176424 @default.
- NCIT_C134987 inSubset NCIT_C177537 @default.
- NCIT_C134987 inSubset NCIT_C63923 @default.
- NCIT_C134987 type Class @default.
- NCIT_C134987 isDefinedBy ncit.owl @default.
- NCIT_C134987 label "Selpercatinib" @default.
- NCIT_C134987 subClassOf NCIT_C129824 @default.
- NCIT_C134987 subClassOf NCIT_C129825 @default.
- NCIT_C134987 subClassOf NCIT_C134987 @default.
- NCIT_C134987 subClassOf NCIT_C1404 @default.
- NCIT_C134987 subClassOf NCIT_C159438 @default.
- NCIT_C134987 subClassOf NCIT_C163758 @default.
- NCIT_C134987 subClassOf NCIT_C1908 @default.
- NCIT_C134987 subClassOf NCIT_C1909 @default.
- NCIT_C134987 subClassOf NCIT_C1967 @default.
- NCIT_C134987 subClassOf NCIT_C2189 @default.
- NCIT_C134987 subClassOf NCIT_C274 @default.
- NCIT_C134987 subClassOf NCIT_C471 @default.