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- NCIT_C135091 IAO_0000115 "A solution consisting of a combination of two toll-like receptor (TLR) ligands: Pam2CSK4 acetate (Pam2), a synthetic diacylated lipopeptide (LP) that is an agonist of TLR2 and TLR6 (TLR2/6) and the TLR9 agonist oligodeoxynucleotide (ODN) M362, which contains unmethylated CpG-based dinucleotides, with potential immunostimulating activity. Upon administration via inhalation of the PUL-042 solution, the components in PUL-042 bind to and activate TLRs on lung epithelial cells. This induces the epithelial cells to produce peptides and reactive oxygen species (ROS) against pathogens, including bacteria, fungi and viruses, that are present in the lungs. M362, through binding of the CpG motifs to TLR9 and subsequent TLR9-mediated signaling, initiates the innate immune system and activates macrophages, natural killer (NK) cells, B-cells, and plasmacytoid dendritic cells (pDCs), stimulates interferon-alpha (IFN-a) production and induces a T-helper 1 cells (Th1)-mediated immune response. Pam2CSK4, through TLR2/6, activates the production of T-helper 2 cells (Th2), leading to the production of Th2-specific cytokines. Altogether, this protects against and kills the pathogens present in the lungs and prevents pulmonary infection. TLRs play fundamental roles in both pathogen recognition and the activation of innate immunity." @default.
- NCIT_C135091 NCIT_A7 NCIT_C30102 @default.
- NCIT_C135091 NCIT_A7 NCIT_C30107 @default.
- NCIT_C135091 NCIT_A7 NCIT_C96048 @default.
- NCIT_C135091 NCIT_NHC0 "C135091" @default.
- NCIT_C135091 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C135091 NCIT_P107 "TLR 2/6/9 Agonist PUL-042" @default.
- NCIT_C135091 NCIT_P108 "TLR 2/6/9 Agonist PUL-042" @default.
- NCIT_C135091 NCIT_P208 "CL522529" @default.
- NCIT_C135091 NCIT_P322 "CTRP" @default.
- NCIT_C135091 NCIT_P329 "788965" @default.
- NCIT_C135091 NCIT_P330 "788965" @default.
- NCIT_C135091 NCIT_P399 "788965" @default.
- NCIT_C135091 normalizedInformationContent "100" @default.
- NCIT_C135091 referenceCount "1" @default.
- NCIT_C135091 hasExactSynonym "Inhalation Solution PUL-042" @default.
- NCIT_C135091 hasExactSynonym "PUL 042" @default.
- NCIT_C135091 hasExactSynonym "PUL-042" @default.
- NCIT_C135091 hasExactSynonym "Pam2/M362 Combination" @default.
- NCIT_C135091 hasExactSynonym "Pam2/M362" @default.
- NCIT_C135091 hasExactSynonym "Pam2CSK4 Acetate/ODN M362 Combination" @default.
- NCIT_C135091 hasExactSynonym "Pam2CSK4 Acetate/ODN M362" @default.
- NCIT_C135091 hasExactSynonym "Solution PUL-042" @default.
- NCIT_C135091 hasExactSynonym "TLR 2/6/9 Agonist PUL-042" @default.
- NCIT_C135091 hasExactSynonym "TLR Agonist PUL-042" @default.
- NCIT_C135091 hasExactSynonym "Toll-like Receptor Agonist PUL-042" @default.
- NCIT_C135091 inSubset NCIT_C116977 @default.
- NCIT_C135091 inSubset NCIT_C116978 @default.
- NCIT_C135091 inSubset NCIT_C173381 @default.
- NCIT_C135091 inSubset NCIT_C173383 @default.
- NCIT_C135091 inSubset NCIT_C176424 @default.
- NCIT_C135091 type Class @default.
- NCIT_C135091 isDefinedBy ncit.owl @default.
- NCIT_C135091 label "TLR 2/6/9 Agonist PUL-042" @default.
- NCIT_C135091 subClassOf NCIT_C135091 @default.
- NCIT_C135091 subClassOf NCIT_C177174 @default.
- NCIT_C135091 subClassOf NCIT_C1908 @default.
- NCIT_C135091 subClassOf NCIT_C1909 @default.
- NCIT_C135091 subClassOf NCIT_C2139 @default.
- NCIT_C135091 subClassOf NCIT_C308 @default.