Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C135612> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- NCIT_C135612 IAO_0000115 "Neural stem cells (NSCs) that are transfected with the gliomatropic oncolytic adenovirus (OV) CRAd-S-pk7, a conditionally replicative oncolytic adenoviral (CRAd) vector that contains the tumor-specific survivin promoter (S) and a fiber protein polylysine modification (pk7), with potential antineoplastic activity. Upon intracerebral administration of NSC loaded with CRAd-S-pk7, the NSCs preferentially migrate towards tumor cells, and the polylysine moiety of the modified fiber protein expressed by the viral vector specifically targets and binds to tumor-specific heparan sulfate proteoglycans. Subsequently, the virus can infect the tumor cells and viral replication is initiated because E1 gene expression is controlled by the tumor-specific promoter for survivin. This results in the specific lysis of the glioma cells. The pk7 fiber modification and the survivin promoter enable tumor-specific infectivity, and transcriptional targeting and preferential replication in glioma cells, while sparing the surrounding normal brain parenchyma. The pK7 is comprised of a heparan sulfate binding domain incorporated into the fiber protein of the adenovirus." @default.
- NCIT_C135612 NCIT_NHC0 "C135612" @default.
- NCIT_C135612 NCIT_P106 "Cell" @default.
- NCIT_C135612 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C135612 NCIT_P107 "Neural Stem Cells-expressing CRAd-S-pk7" @default.
- NCIT_C135612 NCIT_P108 "Neural Stem Cells-expressing CRAd-S-pk7" @default.
- NCIT_C135612 NCIT_P208 "CL522968" @default.
- NCIT_C135612 NCIT_P322 "CTRP" @default.
- NCIT_C135612 NCIT_P329 "788993" @default.
- NCIT_C135612 NCIT_P330 "788993" @default.
- NCIT_C135612 NCIT_P399 "788993" @default.
- NCIT_C135612 normalizedInformationContent "100" @default.
- NCIT_C135612 referenceCount "1" @default.
- NCIT_C135612 hasExactSynonym "CRAd-S-pk7 loaded NSCs" @default.
- NCIT_C135612 hasExactSynonym "NSC-CRAd-S-pk7 Virotherapeutic" @default.
- NCIT_C135612 hasExactSynonym "NSC-CRAd-S-pk7" @default.
- NCIT_C135612 hasExactSynonym "NSCs loaded with CRAd-S-pk7" @default.
- NCIT_C135612 hasExactSynonym "Neural Stem Cells-expressing CRAd-S-pk7" @default.
- NCIT_C135612 hasExactSynonym "SC-CRAd-Survivin-pk7" @default.
- NCIT_C135612 inSubset NCIT_C116977 @default.
- NCIT_C135612 inSubset NCIT_C116978 @default.
- NCIT_C135612 inSubset NCIT_C128784 @default.
- NCIT_C135612 inSubset NCIT_C176424 @default.
- NCIT_C135612 type Class @default.
- NCIT_C135612 isDefinedBy ncit.owl @default.
- NCIT_C135612 label "Neural Stem Cells-expressing CRAd-S-pk7" @default.
- NCIT_C135612 subClassOf NCIT_C129821 @default.
- NCIT_C135612 subClassOf NCIT_C135612 @default.
- NCIT_C135612 subClassOf NCIT_C1908 @default.
- NCIT_C135612 subClassOf NCIT_C1909 @default.
- NCIT_C135612 subClassOf NCIT_C274 @default.
- NCIT_C135612 subClassOf NCIT_C307 @default.
- NCIT_C135612 subClassOf NCIT_C61199 @default.