Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C135627> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- NCIT_C135627 IAO_0000115 "An orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha (HIF-2a), with potential antineoplastic activity. Upon oral administration, belzutifan binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis." @default.
- NCIT_C135627 NCIT_A32 NCIT_C1909 @default.
- NCIT_C135627 NCIT_A7 NCIT_C104306 @default.
- NCIT_C135627 NCIT_NHC0 "C135627" @default.
- NCIT_C135627 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C135627 NCIT_P107 "Belzutifan" @default.
- NCIT_C135627 NCIT_P108 "Belzutifan" @default.
- NCIT_C135627 NCIT_P208 "CL522982" @default.
- NCIT_C135627 NCIT_P210 "1672668-24-4" @default.
- NCIT_C135627 NCIT_P302 "von Hippel-Lindau (VHL) disease-associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET)" @default.
- NCIT_C135627 NCIT_P319 "7K28NB895L" @default.
- NCIT_C135627 NCIT_P322 "CTRP" @default.
- NCIT_C135627 NCIT_P322 "FDA" @default.
- NCIT_C135627 NCIT_P322 "GDC" @default.
- NCIT_C135627 NCIT_P329 "788947" @default.
- NCIT_C135627 NCIT_P330 "788947" @default.
- NCIT_C135627 NCIT_P375 "Belzutifan" @default.
- NCIT_C135627 NCIT_P375 "HIF-2alpha Inhibitor PT2977" @default.
- NCIT_C135627 NCIT_P399 "788947" @default.
- NCIT_C135627 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C135627 referenceCount "2" @default.
- NCIT_C135627 hasExactSynonym "BELZUTIFAN" @default.
- NCIT_C135627 hasExactSynonym "Belzutifan" @default.
- NCIT_C135627 hasExactSynonym "HIF-2alpha Inhibitor PT2977" @default.
- NCIT_C135627 hasExactSynonym "MK 6482" @default.
- NCIT_C135627 hasExactSynonym "MK-6482" @default.
- NCIT_C135627 hasExactSynonym "MK6482" @default.
- NCIT_C135627 hasExactSynonym "PT2977" @default.
- NCIT_C135627 hasExactSynonym "Welireg" @default.
- NCIT_C135627 inSubset NCIT_C116977 @default.
- NCIT_C135627 inSubset NCIT_C116978 @default.
- NCIT_C135627 inSubset NCIT_C128784 @default.
- NCIT_C135627 inSubset NCIT_C157711 @default.
- NCIT_C135627 inSubset NCIT_C157712 @default.
- NCIT_C135627 inSubset NCIT_C176424 @default.
- NCIT_C135627 inSubset NCIT_C177537 @default.
- NCIT_C135627 inSubset NCIT_C63923 @default.
- NCIT_C135627 type Class @default.
- NCIT_C135627 isDefinedBy ncit.owl @default.
- NCIT_C135627 label "Belzutifan" @default.
- NCIT_C135627 subClassOf NCIT_C129824 @default.
- NCIT_C135627 subClassOf NCIT_C135627 @default.
- NCIT_C135627 subClassOf NCIT_C1908 @default.
- NCIT_C135627 subClassOf NCIT_C1909 @default.
- NCIT_C135627 subClassOf NCIT_C192728 @default.
- NCIT_C135627 subClassOf NCIT_C2189 @default.
- NCIT_C135627 subClassOf NCIT_C274 @default.