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- NCIT_C136426 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody against the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells, and linked to an as of yet not fully elucidated chemotherapeutic agent, with potential antineoplastic activity. Upon administration of the ADC PF-06688992, the antibody moiety targets and binds to GD3 expressed on melanoma cells. Upon internalization, the chemotherapeutic agent specifically kills the GD3-positive cells. GD3 represents a major surface marker on most human melanoma cells and is not expressed on most other types of normal, healthy cells." @default.
- NCIT_C136426 NCIT_A32 NCIT_C1909 @default.
- NCIT_C136426 NCIT_A7 NCIT_C39782 @default.
- NCIT_C136426 NCIT_NHC0 "C136426" @default.
- NCIT_C136426 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C136426 NCIT_P107 "Anti-GD3 Antibody-drug Conjugate PF-06688992" @default.
- NCIT_C136426 NCIT_P108 "Anti-GD3 Antibody-drug Conjugate PF-06688992" @default.
- NCIT_C136426 NCIT_P208 "CL523729" @default.
- NCIT_C136426 NCIT_P210 "2249791-21-5" @default.
- NCIT_C136426 NCIT_P319 "X6L6R3CFT8" @default.
- NCIT_C136426 NCIT_P322 "CTRP" @default.
- NCIT_C136426 NCIT_P322 "FDA" @default.
- NCIT_C136426 NCIT_P322 "GDC" @default.
- NCIT_C136426 NCIT_P329 "789230" @default.
- NCIT_C136426 NCIT_P330 "789230" @default.
- NCIT_C136426 NCIT_P375 "Anti-GD3 Antibody-drug Conjugate PF-06688992" @default.
- NCIT_C136426 NCIT_P399 "789230" @default.
- NCIT_C136426 normalizedInformationContent "100" @default.
- NCIT_C136426 referenceCount "1" @default.
- NCIT_C136426 hasExactSynonym "Anti-GD3 ADC PF-06688992" @default.
- NCIT_C136426 hasExactSynonym "Anti-GD3 Antibody-drug Conjugate PF-06688992" @default.
- NCIT_C136426 hasExactSynonym "GD3 ADC PF-06688992" @default.
- NCIT_C136426 hasExactSynonym "PF 06688992" @default.
- NCIT_C136426 hasExactSynonym "PF-06688992" @default.
- NCIT_C136426 inSubset NCIT_C116977 @default.
- NCIT_C136426 inSubset NCIT_C116978 @default.
- NCIT_C136426 inSubset NCIT_C128784 @default.
- NCIT_C136426 inSubset NCIT_C157711 @default.
- NCIT_C136426 inSubset NCIT_C157712 @default.
- NCIT_C136426 inSubset NCIT_C176424 @default.
- NCIT_C136426 inSubset NCIT_C177537 @default.
- NCIT_C136426 inSubset NCIT_C63923 @default.
- NCIT_C136426 type Class @default.
- NCIT_C136426 isDefinedBy ncit.owl @default.
- NCIT_C136426 label "Anti-GD3 Antibody-drug Conjugate PF-06688992" @default.
- NCIT_C136426 subClassOf NCIT_C129821 @default.
- NCIT_C136426 subClassOf NCIT_C129823 @default.
- NCIT_C136426 subClassOf NCIT_C136426 @default.
- NCIT_C136426 subClassOf NCIT_C1512 @default.
- NCIT_C136426 subClassOf NCIT_C1908 @default.
- NCIT_C136426 subClassOf NCIT_C1909 @default.
- NCIT_C136426 subClassOf NCIT_C274 @default.
- NCIT_C136426 subClassOf NCIT_C307 @default.
- NCIT_C136426 subClassOf NCIT_C308 @default.