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- NCIT_C136429 IAO_0000115 "An extended-release (ER), polymer-based injectable formulation containing the indazole derivative granisetron, a selective serotonin (5-hydroxytryptamine; 5-HT) receptor type 3 (5-HT3) antagonist, with anti-emetic activity. Upon subcutaneous administration, granisetron is released from the polymer in a sustained manner, which is based upon the controlled hydrolysis of the polymers, and selectively binds to and inhibits the activity of the 5-HT3 receptors located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema. By preventing stimulation of 5-HT3 receptors, granisetron is able to suppress chemotherapy-induced nausea and vomiting (CINV). Compared to the injection of granisetron alone, injection of the polymer-based formulation allows for therapeutic levels of granisetron over an extended period of time." @default.
- NCIT_C136429 NCIT_NHC0 "C136429" @default.
- NCIT_C136429 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C136429 NCIT_P108 "Extended-release Granisetron Polymer Formulation" @default.
- NCIT_C136429 NCIT_P208 "CL523732" @default.
- NCIT_C136429 NCIT_P329 "789536" @default.
- NCIT_C136429 NCIT_P330 "789536" @default.
- NCIT_C136429 NCIT_P399 "789536" @default.
- NCIT_C136429 normalizedInformationContent "100" @default.
- NCIT_C136429 referenceCount "1" @default.
- NCIT_C136429 hasExactSynonym "ER Granisetron Injectable Formulation" @default.
- NCIT_C136429 hasExactSynonym "Extended-release Granisetron Polymer Formulation" @default.
- NCIT_C136429 hasExactSynonym "Granisetron Extended-release Injection" @default.
- NCIT_C136429 hasExactSynonym "Granisetron Extended-release Polymer-based Injectable Formulation" @default.
- NCIT_C136429 hasExactSynonym "Sustol" @default.
- NCIT_C136429 inSubset NCIT_C176424 @default.
- NCIT_C136429 type Class @default.
- NCIT_C136429 isDefinedBy ncit.owl @default.
- NCIT_C136429 label "Extended-release Granisetron Polymer Formulation" @default.
- NCIT_C136429 subClassOf NCIT_C136429 @default.
- NCIT_C136429 subClassOf NCIT_C1908 @default.
- NCIT_C136429 subClassOf NCIT_C1909 @default.
- NCIT_C136429 subClassOf NCIT_C66885 @default.
- NCIT_C136429 subClassOf NCIT_C78272 @default.
- NCIT_C136429 subClassOf NCIT_C94726 @default.