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- NCIT_C1365 IAO_0000115 "The disodium salt form of dithio-ethane sulfonate, a dimer of mesna and a disulfide bond disrupting agent (DDA), with uroprotective, nephroprotective, chemoprotective, chemosensitizing and chemo-enhancing activities. Upon administration, dimesna is able to modify cysteine on various proteins, such as the kinases EGFR, MET and ROS1, thereby disrupting extracellular disulfide bonds and modulating the activity of these proteins. This inhibits their signaling pathways and downregulates proliferative signaling in cancer cells in which these kinases are overexpressed. This may also enhance the activity of other kinase inhibitors targeting the same proteins. In the kidneys, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis. In addition, dimesna reduces toxicities associated with taxanes and platinum-based chemotherapeutic agents." @default.
- NCIT_C1365 NCIT_NHC0 "C1365" @default.
- NCIT_C1365 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1365 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1365 NCIT_P107 "Dimesna" @default.
- NCIT_C1365 NCIT_P108 "Dimesna" @default.
- NCIT_C1365 NCIT_P175 "716976" @default.
- NCIT_C1365 NCIT_P207 "C0114346" @default.
- NCIT_C1365 NCIT_P210 "16208-51-8" @default.
- NCIT_C1365 NCIT_P302 "Ifosfamide-induced hemorrhagic cystitis, prophylaxis" @default.
- NCIT_C1365 NCIT_P319 "230R951Y4D" @default.
- NCIT_C1365 NCIT_P322 "CTRP" @default.
- NCIT_C1365 NCIT_P322 "FDA" @default.
- NCIT_C1365 NCIT_P325 "A drug that belongs to the family of drugs called chemoprotective agents." @default.
- NCIT_C1365 NCIT_P329 "43236" @default.
- NCIT_C1365 NCIT_P330 "43236" @default.
- NCIT_C1365 NCIT_P350 "C4H8O6S4.2Na" @default.
- NCIT_C1365 NCIT_P366 "Dimesna" @default.
- NCIT_C1365 NCIT_P399 "43236" @default.
- NCIT_C1365 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C1365 referenceCount "3" @default.
- NCIT_C1365 hasExactSynonym "2,2'-Dithio-bis-ethanesulfonate, Disodium Salt" @default.
- NCIT_C1365 hasExactSynonym "2,2'-Dithiobisethanesulfonic Acid, Disodium Salt" @default.
- NCIT_C1365 hasExactSynonym "BNP7787" @default.
- NCIT_C1365 hasExactSynonym "DIMESNA" @default.
- NCIT_C1365 hasExactSynonym "Dimesna" @default.
- NCIT_C1365 hasExactSynonym "LP 300" @default.
- NCIT_C1365 hasExactSynonym "LP-300" @default.
- NCIT_C1365 hasExactSynonym "LP300" @default.
- NCIT_C1365 hasExactSynonym "Mesna Disulfide" @default.
- NCIT_C1365 hasExactSynonym "Tavocept" @default.
- NCIT_C1365 hasExactSynonym "dimesna" @default.
- NCIT_C1365 inSubset NCIT_C116977 @default.
- NCIT_C1365 inSubset NCIT_C116978 @default.
- NCIT_C1365 inSubset NCIT_C176424 @default.
- NCIT_C1365 inSubset NCIT_C63923 @default.
- NCIT_C1365 type Class @default.
- NCIT_C1365 isDefinedBy ncit.owl @default.
- NCIT_C1365 label "Dimesna" @default.
- NCIT_C1365 subClassOf NCIT_C1365 @default.
- NCIT_C1365 subClassOf NCIT_C1908 @default.
- NCIT_C1365 subClassOf NCIT_C1909 @default.
- NCIT_C1365 subClassOf NCIT_C2082 @default.
- NCIT_C1365 subClassOf NCIT_C2459 @default.
- NCIT_C1365 subClassOf NCIT_C26170 @default.