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- NCIT_C136822 IAO_0000115 "An orally available and selective inhibitor of the receptor tyrosine kinases (RTKs) Axl (UFO) and Mer, with potential antineoplastic activity. Upon administration, tamnorzatinib targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with drug resistance and poor prognosis." @default.
- NCIT_C136822 NCIT_NHC0 "C136822" @default.
- NCIT_C136822 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C136822 NCIT_P108 "Tamnorzatinib" @default.
- NCIT_C136822 NCIT_P208 "CL524653" @default.
- NCIT_C136822 NCIT_P210 "1646839-59-9" @default.
- NCIT_C136822 NCIT_P319 "0VCB95RHRV" @default.
- NCIT_C136822 NCIT_P322 "FDA" @default.
- NCIT_C136822 NCIT_P329 "789593" @default.
- NCIT_C136822 NCIT_P330 "789593" @default.
- NCIT_C136822 NCIT_P399 "789593" @default.
- NCIT_C136822 normalizedInformationContent "100" @default.
- NCIT_C136822 referenceCount "1" @default.
- NCIT_C136822 hasExactSynonym "Axl/Mer Inhibitor ONO-7475" @default.
- NCIT_C136822 hasExactSynonym "Axl/Mer RTK Inhibitor ONO-7475" @default.
- NCIT_C136822 hasExactSynonym "ONO 7475" @default.
- NCIT_C136822 hasExactSynonym "ONO-7475" @default.
- NCIT_C136822 hasExactSynonym "TAMNORZATINIB" @default.
- NCIT_C136822 hasExactSynonym "Tamnorzatinib" @default.
- NCIT_C136822 inSubset NCIT_C176424 @default.
- NCIT_C136822 inSubset NCIT_C63923 @default.
- NCIT_C136822 type Class @default.
- NCIT_C136822 isDefinedBy ncit.owl @default.
- NCIT_C136822 label "Tamnorzatinib" @default.
- NCIT_C136822 subClassOf NCIT_C129824 @default.
- NCIT_C136822 subClassOf NCIT_C129825 @default.
- NCIT_C136822 subClassOf NCIT_C136822 @default.
- NCIT_C136822 subClassOf NCIT_C1404 @default.
- NCIT_C136822 subClassOf NCIT_C1908 @default.
- NCIT_C136822 subClassOf NCIT_C1909 @default.
- NCIT_C136822 subClassOf NCIT_C1967 @default.
- NCIT_C136822 subClassOf NCIT_C200418 @default.
- NCIT_C136822 subClassOf NCIT_C2189 @default.
- NCIT_C136822 subClassOf NCIT_C274 @default.
- NCIT_C136822 subClassOf NCIT_C471 @default.