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- NCIT_C136987 IAO_0000115 "An antibody-drug conjugate (ADC) composed of patritumab, a monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3),linked to the topoisomerase I inhibitor DX 8951, a semisynthetic, water-soluble derivative of camptothecin, with potential antineoplastic activity. Upon administration of patritumab deruxtecan, the patritumab moiety targets and binds to HER3. After internalization, DX 8951 inhibits topoisomerase I activity by stabilizing the complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors." @default.
- NCIT_C136987 NCIT_A32 NCIT_C1909 @default.
- NCIT_C136987 NCIT_A7 NCIT_C18490 @default.
- NCIT_C136987 NCIT_NHC0 "C136987" @default.
- NCIT_C136987 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C136987 NCIT_P107 "Patritumab Deruxtecan" @default.
- NCIT_C136987 NCIT_P108 "Patritumab Deruxtecan" @default.
- NCIT_C136987 NCIT_P208 "CL524745" @default.
- NCIT_C136987 NCIT_P210 "2227102-46-5" @default.
- NCIT_C136987 NCIT_P319 "3XPI7EG4W8" @default.
- NCIT_C136987 NCIT_P322 "CTRP" @default.
- NCIT_C136987 NCIT_P322 "FDA" @default.
- NCIT_C136987 NCIT_P322 "GDC" @default.
- NCIT_C136987 NCIT_P329 "789807" @default.
- NCIT_C136987 NCIT_P330 "789807" @default.
- NCIT_C136987 NCIT_P375 "Anti-HER3 Antibody-drug Conjugate U3 1402" @default.
- NCIT_C136987 NCIT_P375 "Patritumab Deruxtecan" @default.
- NCIT_C136987 NCIT_P399 "789807" @default.
- NCIT_C136987 normalizedInformationContent "100" @default.
- NCIT_C136987 referenceCount "1" @default.
- NCIT_C136987 hasExactSynonym "Anti-HER3 Antibody-drug Conjugate U3 1402" @default.
- NCIT_C136987 hasExactSynonym "PATRITUMAB DERUXTECAN" @default.
- NCIT_C136987 hasExactSynonym "Patritumab Deruxtecan" @default.
- NCIT_C136987 hasExactSynonym "U3 1402" @default.
- NCIT_C136987 hasExactSynonym "U3-1402" @default.
- NCIT_C136987 hasExactSynonym "U3-1402a" @default.
- NCIT_C136987 inSubset NCIT_C116977 @default.
- NCIT_C136987 inSubset NCIT_C116978 @default.
- NCIT_C136987 inSubset NCIT_C128784 @default.
- NCIT_C136987 inSubset NCIT_C157711 @default.
- NCIT_C136987 inSubset NCIT_C157712 @default.
- NCIT_C136987 inSubset NCIT_C176424 @default.
- NCIT_C136987 inSubset NCIT_C177537 @default.
- NCIT_C136987 inSubset NCIT_C63923 @default.
- NCIT_C136987 type Class @default.
- NCIT_C136987 isDefinedBy ncit.owl @default.
- NCIT_C136987 label "Patritumab Deruxtecan" @default.
- NCIT_C136987 subClassOf NCIT_C129821 @default.
- NCIT_C136987 subClassOf NCIT_C129823 @default.
- NCIT_C136987 subClassOf NCIT_C136987 @default.
- NCIT_C136987 subClassOf NCIT_C1512 @default.
- NCIT_C136987 subClassOf NCIT_C163758 @default.
- NCIT_C136987 subClassOf NCIT_C1908 @default.
- NCIT_C136987 subClassOf NCIT_C1909 @default.
- NCIT_C136987 subClassOf NCIT_C199383 @default.
- NCIT_C136987 subClassOf NCIT_C199385 @default.
- NCIT_C136987 subClassOf NCIT_C274 @default.
- NCIT_C136987 subClassOf NCIT_C307 @default.
- NCIT_C136987 subClassOf NCIT_C308 @default.