Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C13719> ?p ?o ?g. }
Showing items 1 to 20 of
20
with 100 items per page.
- NCIT_C13719 IAO_0000115 "Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI)" @default.
- NCIT_C13719 NCIT_NHC0 "C13719" @default.
- NCIT_C13719 NCIT_P106 "Amino Acid Sequence" @default.
- NCIT_C13719 NCIT_P108 "ETS Domain" @default.
- NCIT_C13719 NCIT_P207 "C1512142" @default.
- NCIT_C13719 NCIT_P366 "ETS_Domain" @default.
- NCIT_C13719 normalizedInformationContent "79.251926409996102" @default.
- NCIT_C13719 referenceCount "23" @default.
- NCIT_C13719 hasExactSynonym "ETS Domain" @default.
- NCIT_C13719 type Class @default.
- NCIT_C13719 isDefinedBy ncit.owl @default.
- NCIT_C13719 label "ETS Domain" @default.
- NCIT_C13719 subClassOf NCIT_C12219 @default.
- NCIT_C13719 subClassOf NCIT_C13303 @default.
- NCIT_C13719 subClassOf NCIT_C13379 @default.
- NCIT_C13719 subClassOf NCIT_C13425 @default.
- NCIT_C13719 subClassOf NCIT_C13671 @default.
- NCIT_C13719 subClassOf NCIT_C13719 @default.
- NCIT_C13719 subClassOf NCIT_C14134 @default.
- NCIT_C13719 subClassOf NCIT_C21599 @default.