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- NCIT_C137825 IAO_0000115 "The mesylate salt form of enasidenib, an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, enasidenib specifically inhibits various mutant forms of IDH2, including the IDH2 variants R140Q, R172S, and R172K, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG." @default.
- NCIT_C137825 NCIT_A32 NCIT_C1909 @default.
- NCIT_C137825 NCIT_A6 NCIT_C111573 @default.
- NCIT_C137825 NCIT_A7 NCIT_C117279 @default.
- NCIT_C137825 NCIT_A7 NCIT_C84990 @default.
- NCIT_C137825 NCIT_NHC0 "C137825" @default.
- NCIT_C137825 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C137825 NCIT_P107 "Enasidenib Mesylate" @default.
- NCIT_C137825 NCIT_P108 "Enasidenib Mesylate" @default.
- NCIT_C137825 NCIT_P208 "CL524900" @default.
- NCIT_C137825 NCIT_P210 "1650550-25-6" @default.
- NCIT_C137825 NCIT_P302 "adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 (IDH2) mutation" @default.
- NCIT_C137825 NCIT_P319 "UF6PC17XAV" @default.
- NCIT_C137825 NCIT_P322 "CTRP" @default.
- NCIT_C137825 NCIT_P322 "FDA" @default.
- NCIT_C137825 NCIT_P322 "GDC" @default.
- NCIT_C137825 NCIT_P329 "752247" @default.
- NCIT_C137825 NCIT_P330 "752247" @default.
- NCIT_C137825 NCIT_P375 "Enasidenib Mesylate" @default.
- NCIT_C137825 NCIT_P399 "752247" @default.
- NCIT_C137825 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C137825 referenceCount "2" @default.
- NCIT_C137825 hasExactSynonym "2-Methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol Methanesulfonate" @default.
- NCIT_C137825 hasExactSynonym "2-Propanol, 2-Methyl-1-((4-(6-(trifluoromethyl)-2-pyridinyl)-6-((2-(trifluoromethyl)-4-pyridinyl)amino)-1,3,5-triazin-2-yl)amino)-, Methanesulfonate (1:1)" @default.
- NCIT_C137825 hasExactSynonym "AG-221 Mesylate" @default.
- NCIT_C137825 hasExactSynonym "CC-90007" @default.
- NCIT_C137825 hasExactSynonym "ENASIDENIB MESYLATE" @default.
- NCIT_C137825 hasExactSynonym "Enasidenib Mesylate" @default.
- NCIT_C137825 hasExactSynonym "Enasidenib Methanesulfonate" @default.
- NCIT_C137825 hasExactSynonym "Idhifa" @default.
- NCIT_C137825 inSubset NCIT_C116977 @default.
- NCIT_C137825 inSubset NCIT_C116978 @default.
- NCIT_C137825 inSubset NCIT_C157711 @default.
- NCIT_C137825 inSubset NCIT_C157712 @default.
- NCIT_C137825 inSubset NCIT_C176424 @default.
- NCIT_C137825 inSubset NCIT_C177537 @default.
- NCIT_C137825 inSubset NCIT_C63923 @default.
- NCIT_C137825 type Class @default.
- NCIT_C137825 isDefinedBy ncit.owl @default.
- NCIT_C137825 label "Enasidenib Mesylate" @default.
- NCIT_C137825 subClassOf NCIT_C129824 @default.
- NCIT_C137825 subClassOf NCIT_C129825 @default.
- NCIT_C137825 subClassOf NCIT_C137825 @default.
- NCIT_C137825 subClassOf NCIT_C137826 @default.
- NCIT_C137825 subClassOf NCIT_C163758 @default.
- NCIT_C137825 subClassOf NCIT_C168619 @default.
- NCIT_C137825 subClassOf NCIT_C1908 @default.
- NCIT_C137825 subClassOf NCIT_C1909 @default.
- NCIT_C137825 subClassOf NCIT_C2189 @default.
- NCIT_C137825 subClassOf NCIT_C274 @default.
- NCIT_C137825 subClassOf NCIT_C471 @default.