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- NCIT_C137863 IAO_0000115 "A preparation of pharmacologically-enriched, allogeneic natural killer (NK) cells derived from a related but not completely matched human leukocyte antigen (HLA)-haploidentical donor that is seropositive for cytomegalovirus (CMV+), with potential cytolytic and antineoplastic activities. Upon leukapheresis, the donor peripheral blood mononuclear cells (PBMCs) are treated to remove T-lymphocytes (CD3+) and B-lymphocytes (CD19+). The remaining leukocytes are cultured for 7 days with the cytokine interleukin-15 (IL-15) and a small molecule inhibitor of glycogen synthase kinase 3-beta (GSK3beta) to generate the adaptive, CD3- CD19- CD57+ NKG2C+ NK cells FATE-NK100 ex vivo. Upon infusion of the allogeneic CD3- CD19- CD57+ NKG2C+ NK cells FATE-NK100, these cells selectively recognize and bind to tumor cells, and secrete perforins, granzymes, and cytokines, which results in cancer cell lysis. Exposure to CMV induces the expression of the memory-like activating receptor NKG2C and the maturation marker CD57 in the isolated NK cells, making them more potent than those not pre-exposed to CMV. CD57 both enhances the effector function of NK cells and stimulates CD16-dependent signaling. Treatment with IL-15 enhances NK cell proliferation and survival. The GSK3beta inhibitor induces preferential expansion of CD57+ NK cells that exhibit enhanced interferon (IFN)-gamma production." @default.
- NCIT_C137863 NCIT_A32 NCIT_C1909 @default.
- NCIT_C137863 NCIT_NHC0 "C137863" @default.
- NCIT_C137863 NCIT_P106 "Cell" @default.
- NCIT_C137863 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C137863 NCIT_P107 "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100" @default.
- NCIT_C137863 NCIT_P108 "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100" @default.
- NCIT_C137863 NCIT_P208 "CL524941" @default.
- NCIT_C137863 NCIT_P322 "CTRP" @default.
- NCIT_C137863 NCIT_P322 "GDC" @default.
- NCIT_C137863 NCIT_P329 "790374" @default.
- NCIT_C137863 NCIT_P330 "790374" @default.
- NCIT_C137863 NCIT_P375 "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100" @default.
- NCIT_C137863 NCIT_P399 "790374" @default.
- NCIT_C137863 normalizedInformationContent "100" @default.
- NCIT_C137863 referenceCount "1" @default.
- NCIT_C137863 hasExactSynonym "Adaptive Memory NKs Cells FATE-NK100" @default.
- NCIT_C137863 hasExactSynonym "Adaptive Memory Natural Killer Cells FATE-NK100" @default.
- NCIT_C137863 hasExactSynonym "Adaptive NKs Cells FATE-NK100" @default.
- NCIT_C137863 hasExactSynonym "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100" @default.
- NCIT_C137863 hasExactSynonym "FATE NK100" @default.
- NCIT_C137863 hasExactSynonym "FATE-NK100" @default.
- NCIT_C137863 inSubset NCIT_C116977 @default.
- NCIT_C137863 inSubset NCIT_C116978 @default.
- NCIT_C137863 inSubset NCIT_C128784 @default.
- NCIT_C137863 inSubset NCIT_C157711 @default.
- NCIT_C137863 inSubset NCIT_C157712 @default.
- NCIT_C137863 inSubset NCIT_C176424 @default.
- NCIT_C137863 inSubset NCIT_C177537 @default.
- NCIT_C137863 type Class @default.
- NCIT_C137863 isDefinedBy ncit.owl @default.
- NCIT_C137863 label "Allogeneic CD3- CD19- CD57+ NKG2C+ NK Cells FATE-NK100" @default.
- NCIT_C137863 subClassOf NCIT_C129820 @default.
- NCIT_C137863 subClassOf NCIT_C129821 @default.
- NCIT_C137863 subClassOf NCIT_C129826 @default.
- NCIT_C137863 subClassOf NCIT_C137863 @default.
- NCIT_C137863 subClassOf NCIT_C142078 @default.
- NCIT_C137863 subClassOf NCIT_C1908 @default.
- NCIT_C137863 subClassOf NCIT_C1909 @default.
- NCIT_C137863 subClassOf NCIT_C201545 @default.
- NCIT_C137863 subClassOf NCIT_C274 @default.
- NCIT_C137863 subClassOf NCIT_C28676 @default.
- NCIT_C137863 subClassOf NCIT_C307 @default.
- NCIT_C137863 subClassOf NCIT_C308 @default.