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- NCIT_C137866 IAO_0000115 "A preparation of a defined ratio of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv), derived from the CD19-specific murine immunoglobulin (Ig) G1 monoclonal antibody FMC63, fused to the signaling domain of CD28, the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T-cells are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response." @default.
- NCIT_C137866 NCIT_A7 NCIT_C38894 @default.
- NCIT_C137866 NCIT_NHC0 "C137866" @default.
- NCIT_C137866 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C137866 NCIT_P107 "Autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T Cells" @default.
- NCIT_C137866 NCIT_P108 "Autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T Cells" @default.
- NCIT_C137866 NCIT_P208 "CL524940" @default.
- NCIT_C137866 NCIT_P322 "CTRP" @default.
- NCIT_C137866 NCIT_P399 "810777" @default.
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- NCIT_C137866 NCIT_R72 NCIT_C12476 @default.
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- NCIT_C137866 NCIT_R72 NCIT_C12535 @default.
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- NCIT_C137866 NCIT_R72 NCIT_C33061 @default.
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- NCIT_C137866 normalizedInformationContent "100" @default.
- NCIT_C137866 referenceCount "1" @default.
- NCIT_C137866 hasExactSynonym "Autologous Anti-CD19CAR-CD28-CD3zeta-EGFRt-expressing CD4+/CD8+ T-lymphocytes" @default.
- NCIT_C137866 hasExactSynonym "Autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T Cells" @default.
- NCIT_C137866 inSubset NCIT_C116977 @default.
- NCIT_C137866 inSubset NCIT_C116978 @default.
- NCIT_C137866 inSubset NCIT_C128784 @default.
- NCIT_C137866 inSubset NCIT_C176424 @default.
- NCIT_C137866 type Class @default.
- NCIT_C137866 isDefinedBy ncit.owl @default.
- NCIT_C137866 label "Autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T Cells" @default.
- NCIT_C137866 subClassOf NCIT_C129820 @default.
- NCIT_C137866 subClassOf NCIT_C129821 @default.
- NCIT_C137866 subClassOf NCIT_C129826 @default.
- NCIT_C137866 subClassOf NCIT_C137866 @default.
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- NCIT_C137866 subClassOf NCIT_C142078 @default.
- NCIT_C137866 subClassOf NCIT_C154231 @default.
- NCIT_C137866 subClassOf NCIT_C176018 @default.
- NCIT_C137866 subClassOf NCIT_C1908 @default.
- NCIT_C137866 subClassOf NCIT_C1909 @default.
- NCIT_C137866 subClassOf NCIT_C1962 @default.
- NCIT_C137866 subClassOf NCIT_C200766 @default.
- NCIT_C137866 subClassOf NCIT_C274 @default.
- NCIT_C137866 subClassOf NCIT_C28681 @default.
- NCIT_C137866 subClassOf NCIT_C307 @default.
- NCIT_C137866 subClassOf NCIT_C308 @default.