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- NCIT_C137988 IAO_0000115 "The succinate salt form of FF-10101, a FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) inhibitor, with potential antineoplastic activity. Upon administration of FLT3 inhibitor FF-10101 succinate (FF-10101-01), FF-10101 irreversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B lineage neoplasms and in acute myeloid leukemias." @default.
- NCIT_C137988 NCIT_A32 NCIT_C1909 @default.
- NCIT_C137988 NCIT_A7 NCIT_C26202 @default.
- NCIT_C137988 NCIT_NHC0 "C137988" @default.
- NCIT_C137988 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C137988 NCIT_P107 "FLT3 Inhibitor FF-10101 Succinate" @default.
- NCIT_C137988 NCIT_P108 "FLT3 Inhibitor FF-10101 Succinate" @default.
- NCIT_C137988 NCIT_P208 "CL524957" @default.
- NCIT_C137988 NCIT_P322 "CTRP" @default.
- NCIT_C137988 NCIT_P322 "GDC" @default.
- NCIT_C137988 NCIT_P329 "790705" @default.
- NCIT_C137988 NCIT_P330 "790705" @default.
- NCIT_C137988 NCIT_P375 "FLT3 Inhibitor FF-10101 Succinate" @default.
- NCIT_C137988 NCIT_P399 "790705" @default.
- NCIT_C137988 normalizedInformationContent "100" @default.
- NCIT_C137988 referenceCount "1" @default.
- NCIT_C137988 hasExactSynonym "FF-10101 Succinate" @default.
- NCIT_C137988 hasExactSynonym "FF-10101-01" @default.
- NCIT_C137988 hasExactSynonym "FF10101 Succinate" @default.
- NCIT_C137988 hasExactSynonym "FLT3 Inhibitor FF-10101 Succinate" @default.
- NCIT_C137988 inSubset NCIT_C116977 @default.
- NCIT_C137988 inSubset NCIT_C116978 @default.
- NCIT_C137988 inSubset NCIT_C128784 @default.
- NCIT_C137988 inSubset NCIT_C157711 @default.
- NCIT_C137988 inSubset NCIT_C157712 @default.
- NCIT_C137988 inSubset NCIT_C176424 @default.
- NCIT_C137988 inSubset NCIT_C177537 @default.
- NCIT_C137988 type Class @default.
- NCIT_C137988 isDefinedBy ncit.owl @default.
- NCIT_C137988 label "FLT3 Inhibitor FF-10101 Succinate" @default.
- NCIT_C137988 subClassOf NCIT_C124800 @default.
- NCIT_C137988 subClassOf NCIT_C137988 @default.
- NCIT_C137988 subClassOf NCIT_C1404 @default.
- NCIT_C137988 subClassOf NCIT_C163758 @default.
- NCIT_C137988 subClassOf NCIT_C163790 @default.
- NCIT_C137988 subClassOf NCIT_C1908 @default.
- NCIT_C137988 subClassOf NCIT_C1909 @default.
- NCIT_C137988 subClassOf NCIT_C1967 @default.
- NCIT_C137988 subClassOf NCIT_C274 @default.
- NCIT_C137988 subClassOf NCIT_C471 @default.