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- NCIT_C137989 IAO_0000115 "An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, AZD5991 binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins, and promoting apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival." @default.
- NCIT_C137989 NCIT_A32 NCIT_C1909 @default.
- NCIT_C137989 NCIT_NHC0 "C137989" @default.
- NCIT_C137989 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C137989 NCIT_P108 "Mcl-1 Inhibitor AZD5991" @default.
- NCIT_C137989 NCIT_P208 "CL524956" @default.
- NCIT_C137989 NCIT_P210 "2143010-83-5" @default.
- NCIT_C137989 NCIT_P319 "E3T5XXY9HX" @default.
- NCIT_C137989 NCIT_P322 "FDA" @default.
- NCIT_C137989 NCIT_P322 "GDC" @default.
- NCIT_C137989 NCIT_P329 "790242" @default.
- NCIT_C137989 NCIT_P330 "790242" @default.
- NCIT_C137989 NCIT_P375 "Mcl-1 Inhibitor AZD5991" @default.
- NCIT_C137989 NCIT_P399 "790242" @default.
- NCIT_C137989 normalizedInformationContent "100" @default.
- NCIT_C137989 referenceCount "1" @default.
- NCIT_C137989 hasExactSynonym "AZD-5991" @default.
- NCIT_C137989 hasExactSynonym "AZD5991" @default.
- NCIT_C137989 hasExactSynonym "MCL1 Inhibitor AZD5991" @default.
- NCIT_C137989 hasExactSynonym "Mcl-1 Inhibitor AZD5991" @default.
- NCIT_C137989 inSubset NCIT_C128784 @default.
- NCIT_C137989 inSubset NCIT_C157711 @default.
- NCIT_C137989 inSubset NCIT_C157712 @default.
- NCIT_C137989 inSubset NCIT_C176424 @default.
- NCIT_C137989 inSubset NCIT_C177537 @default.
- NCIT_C137989 inSubset NCIT_C63923 @default.
- NCIT_C137989 type Class @default.
- NCIT_C137989 isDefinedBy ncit.owl @default.
- NCIT_C137989 label "Mcl-1 Inhibitor AZD5991" @default.
- NCIT_C137989 subClassOf NCIT_C129839 @default.
- NCIT_C137989 subClassOf NCIT_C137989 @default.
- NCIT_C137989 subClassOf NCIT_C137990 @default.
- NCIT_C137989 subClassOf NCIT_C1908 @default.
- NCIT_C137989 subClassOf NCIT_C1909 @default.
- NCIT_C137989 subClassOf NCIT_C192025 @default.
- NCIT_C137989 subClassOf NCIT_C274 @default.