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- NCIT_C138066 IAO_0000115 "An orally available reversible inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase), with potential antineoplastic activity. Upon administration, nemtabrutinib non-covalently binds to and inhibits the activity of both the wild-type and the C481S mutated form of BTK, a resistance mutation in the BTK active site in which cysteine is substituted for serine at residue 481. This prevents the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. Compared to other BTK inhibitors, nemtabrutinib does not require interaction with the BTK C481 site and inhibits the proliferation of cells harboring the BTK C481S mutation. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes." @default.
- NCIT_C138066 NCIT_A32 NCIT_C1909 @default.
- NCIT_C138066 NCIT_A7 NCIT_C75017 @default.
- NCIT_C138066 NCIT_NHC0 "C138066" @default.
- NCIT_C138066 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C138066 NCIT_P107 "Nemtabrutinib" @default.
- NCIT_C138066 NCIT_P108 "Nemtabrutinib" @default.
- NCIT_C138066 NCIT_P208 "CL525087" @default.
- NCIT_C138066 NCIT_P210 "2095393-15-8" @default.
- NCIT_C138066 NCIT_P319 "JTZ51LIXN4" @default.
- NCIT_C138066 NCIT_P322 "CTRP" @default.
- NCIT_C138066 NCIT_P322 "FDA" @default.
- NCIT_C138066 NCIT_P322 "GDC" @default.
- NCIT_C138066 NCIT_P329 "790667" @default.
- NCIT_C138066 NCIT_P330 "790667" @default.
- NCIT_C138066 NCIT_P375 "BTK Inhibitor ARQ 531" @default.
- NCIT_C138066 NCIT_P399 "790667" @default.
- NCIT_C138066 normalizedInformationContent "100" @default.
- NCIT_C138066 referenceCount "1" @default.
- NCIT_C138066 hasExactSynonym "ARQ 531" @default.
- NCIT_C138066 hasExactSynonym "ARQ-531" @default.
- NCIT_C138066 hasExactSynonym "ARQ531" @default.
- NCIT_C138066 hasExactSynonym "BTK Inhibitor ARQ 531" @default.
- NCIT_C138066 hasExactSynonym "Bruton's Tyrosine Kinase Inhibitor ARQ 531" @default.
- NCIT_C138066 hasExactSynonym "MK-1026" @default.
- NCIT_C138066 hasExactSynonym "NEMTABRUTINIB" @default.
- NCIT_C138066 hasExactSynonym "Nemtabrutinib" @default.
- NCIT_C138066 inSubset NCIT_C116977 @default.
- NCIT_C138066 inSubset NCIT_C116978 @default.
- NCIT_C138066 inSubset NCIT_C128784 @default.
- NCIT_C138066 inSubset NCIT_C157711 @default.
- NCIT_C138066 inSubset NCIT_C157712 @default.
- NCIT_C138066 inSubset NCIT_C176424 @default.
- NCIT_C138066 inSubset NCIT_C177537 @default.
- NCIT_C138066 inSubset NCIT_C63923 @default.
- NCIT_C138066 type Class @default.
- NCIT_C138066 isDefinedBy ncit.owl @default.
- NCIT_C138066 label "Nemtabrutinib" @default.
- NCIT_C138066 subClassOf NCIT_C124801 @default.
- NCIT_C138066 subClassOf NCIT_C138066 @default.
- NCIT_C138066 subClassOf NCIT_C1404 @default.
- NCIT_C138066 subClassOf NCIT_C163758 @default.
- NCIT_C138066 subClassOf NCIT_C163774 @default.
- NCIT_C138066 subClassOf NCIT_C1908 @default.
- NCIT_C138066 subClassOf NCIT_C1909 @default.
- NCIT_C138066 subClassOf NCIT_C1967 @default.
- NCIT_C138066 subClassOf NCIT_C274 @default.
- NCIT_C138066 subClassOf NCIT_C471 @default.